ID   U3JPR7_FICAL            Unreviewed;       836 AA.
AC   U3JPR7;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=Carboxylesterase type B domain-containing protein {ECO:0000259|Pfam:PF00135};
GN   Name=NLGN4X {ECO:0000313|Ensembl:ENSFALP00000004771.1};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000004771.1, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000004771.1, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000004771.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|ARBA:ARBA00005964}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_005037482.1; XM_005037425.2.
DR   AlphaFoldDB; U3JPR7; -.
DR   STRING; 59894.ENSFALP00000004771; -.
DR   ESTHER; fical-u3jpr7; Neuroligin.
DR   MEROPS; S09.989; -.
DR   Ensembl; ENSFALT00000004795.2; ENSFALP00000004771.1; ENSFALG00000004580.2.
DR   GeneID; 101808242; -.
DR   KEGG; fab:101808242; -.
DR   CTD; 57502; -.
DR   eggNOG; KOG1516; Eukaryota.
DR   GeneTree; ENSGT00940000156607; -.
DR   HOGENOM; CLU_006586_5_1_1; -.
DR   OMA; HQQHMQN; -.
DR   OrthoDB; 4386at2759; -.
DR   Proteomes; UP000016665; Chromosome 1.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042043; F:neurexin family protein binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007416; P:synapse assembly; IEA:UniProt.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019819; Carboxylesterase_B_CS.
DR   InterPro; IPR000460; Nlgn.
DR   PANTHER; PTHR43903; NEUROLIGIN; 1.
DR   PANTHER; PTHR43903:SF10; NEUROLIGIN-4, Y-LINKED; 1.
DR   Pfam; PF00135; COesterase; 1.
DR   PRINTS; PR01090; NEUROLIGIN.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        695..718
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          45..610
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
FT   REGION          160..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          652..675
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   836 AA;  93945 MW;  2BFC1CD3ABD47D32 CRC64;
     MSKPMGLLWL PLIFTPVCVM LNSSFLLWIT ALAIRFTLID GQAQYPVVTT NYGKIRGLRT
     PLPNEILGPV EQYLGVPYAS PPTGERRFQP PEPPSSWTGV RNATQFAAVC PQYLDERSLL
     NDMLPVWFTA NLDTVVTYVQ DQNEDCLYLN IYVPTEDGAN TKKSADDITS NDRGEDEDIH
     DQNSKKPVMV YIHGGSYMEG TGNMIDGSIL ASYGNVIVVT INYRLGVLGF LSTGDQAAKG
     NYGLLDQIQA LRWIEENIGS FGGDPKRVTI FGSGAGASCV SLLTLSHYSE GLFQKAIIQS
     GTALSSWAVN YQPAKYTRIL ADKVGCDMLD TTDLVECLRN KNYKELIQQT ITPATYHIAF
     GPVIDGDVIP DDPQILMEQG EFLNYDIMLG VNQGEGLKFV DGIVDNEDGV SPNDFDFSVS
     NFVDNLYGYP EGKDTLRETI KFMYTDWADK ENPETRRKTL VALFTDHQWV APAVATADLH
     AQYGSPTYFY AFYHHCQSEM KPSWADSAHG DEVPYVFGIP MIGPTELFNC NFSKNDVMLS
     AVVMTYWTNF AKTGDPNQPV PQDTKFIHTK PNRFEEVAWS KYNPKDQLYL HIGLKPRVRD
     HYRATKVAFW LELVPHLHNL NEIFQYVSTT TKVPPPDMTS FPYVTRRSPG KLWPATKRPA
     MTPANNPKHS KDTHKTAPED TTVLIENKRD YSTELSVTIA VGASLLFLNI LAFAALYYKK
     DKRRHETHRR PSPQRNTTND IAHIQNEEIM SLQMKQLEHD HECESLQAHD TLRLTCPPDY
     TLTLRRSPDD IPLMTPNTIT MIPNTLTGMQ PLHTFNTFSG GQNSTNLPHG HSTTRV
//