ID U3JRI5_FICAL Unreviewed; 936 AA.
AC U3JRI5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN Name=GABBR2 {ECO:0000313|Ensembl:ENSFALP00000005389.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000005389.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000005389.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000005389.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR RefSeq; XP_005041890.1; XM_005041833.2.
DR AlphaFoldDB; U3JRI5; -.
DR STRING; 59894.ENSFALP00000005389; -.
DR Ensembl; ENSFALT00000005415.2; ENSFALP00000005389.2; ENSFALG00000005156.2.
DR GeneID; 101816888; -.
DR KEGG; fab:101816888; -.
DR CTD; 9568; -.
DR eggNOG; KOG1055; Eukaryota.
DR GeneTree; ENSGT00940000155783; -.
DR HOGENOM; CLU_005240_0_0_1; -.
DR Proteomes; UP000016665; Chromosome 2.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd15294; 7tmC_GABA-B-R2; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR041689; GBR2_CC.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR002457; GPCR_3_GABA_rcpt_B2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF18455; GBR2_CC; 1.
DR PRINTS; PR01178; GABAB2RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..936
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5032435974"
FT TRANSMEM 474..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 592..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 691..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 713..736
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 476..758
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 758..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 854..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..786
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 936 AA; 105643 MW; F4B984ABF33D0BB0 CRC64;
MHPSPRRPAA ATSNPAMLLL LLCLGWAPPG WGWPRGSSRG AAGLPPNATT PISIMGLMPL
SQSEEDQKSR IGRGVLPAVQ LAMDQIRNES LLNPYFLDLR LYDTECDNAK GLKAFYDAIK
YGPNHLMVFG GVCATVTSII AESLKGWNLV QLSFAATTPE LADKKKYPYF FRTVPSDNAV
NPAILKLLKH YHWKRVGTLT QDVQRFSEVR NDLTGVLYGE DIEISDTESF SNDPCTSVKK
LKGNDVRIIL GQFDEEMAVK VFCCAYDEEM YGSKYQWIIP GWYENLWWES WINSSQCLSK
NLLAAMEGYI GVDFEPLSSK TNKTISGRTP QQYEKEYNAK RGDGQSSKFH GYAYDGIWVI
ARTLQRAMNY LNSTNKHQKI EDFNYTNHKL GKIFLNAMNE TRFFGVTGEV VFRNGERMGT
IKFTQFQEQK EVKVGEYNAV DDKLVIINNS IRFQGLEPPK DKTIIQEELR KISLPLYSIL
SALTILGMIM ASAFLFFNIK NRNQKLIKMS SPYMNNLIIL GGMLSYASIF LFGLDGSFVS
EKTFETLCTV RTWILTVGYT TAFGAMFAKT WRVHAIFKNV KMKKKIIKDQ KLLGIVGGML
LIDLCILICW QVVDPLRRTV EKYNMEPDPA GRDISIRPIL EHCENTHMTI WLGIVYAYKG
LLMLFGCFLA WETRNVSIPA LNDSKYIGMS VYNVGIMCII GAAVSFLTRD QPNVQFCIVA
LVIIFCSTIT LCLVFVPKLI TLRTNPDAAT QNRRFQFTQN QKKEDSKTST SVTSVNQAST
SRLEGLQSEN HRLRMKITEL DKDLEEVTMQ LQDTPEKTTY IKQNHYQDLN DILSIRNFTD
GKDGEKAILK NHLDQNPPAQ WGSSDPSRTS KDPIEDINSP EHIQRRLSLQ LPILHHAYLP
SIGGVDASCA SPCVSPSASP RHRHVPPSFR VMVSGL
//
