ID U3JTC7_FICAL Unreviewed; 4097 AA.
AC U3JTC7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000256|ARBA:ARBA00018077};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=PRKDC {ECO:0000313|Ensembl:ENSFALP00000006031.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000006031.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000006031.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000006031.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031}.
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DR STRING; 59894.ENSFALP00000006031; -.
DR Ensembl; ENSFALT00000006058.2; ENSFALP00000006031.2; ENSFALG00000005785.2.
DR eggNOG; KOG0891; Eukaryota.
DR GeneTree; ENSGT00940000155633; -.
DR HOGENOM; CLU_224534_0_0_1; -.
DR Proteomes; UP000016665; Chromosome 2.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2875..3507
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3690..4022
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 4065..4097
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 2575..2598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4097 AA; 467778 MW; 653680712991C311 CRC64;
AALHLSLVFS QEHGLLVFIH RSLTIEEFRD CREEALKFLS VFMEKAENVI FEFPSLLTGI
VILIFVSVAA KCKISALELL IKLLHSLQRS CLMEEMKVRE IFNKFYGELA AKSKIPDTVL
EKIYELLGVL GEVQPGDMIN NSEKLFRAYL GELRTQMTSA TRGPKLPLVA GCLRGLVALM
YNFTKSVDED PQTAKEIFDF AMKAINPQID QKRYAVPLAG LQLFIWHSAQ FGALLMDNYV
YLYEVMCKWC GHTHQELKKA SYSALDSFIK QISLMVAKDA ELHKSKLQFF MEQFYGIIRR
MDSTSKELSI AIRGYGFFAA PCKAIHSEDV DSMYVELLQR CKQMFLTEAE TIDDHLYQLP
SFLQSIASVI FHIDTIPEVY TPVLEHLVVL QISSFPQYSE KMQPVCFRSI IKVFLSLSGK
GPVLWSFIST VVHQGLIRIF SKPVTFSKDL FGKETSGSEE AFEAGEVGTR AFEAGEAGTG
RSKVPTYKDY LYLFRSLLGC DTIKECVFED ADFLTENAQL QSLSHVLYDE FIKSVLKIIE
KLDLTLQKLD VSEQEENAGD SALISPSSDP ASNLQPTKPV DFIAFINLVE FCREILLEKH
VEYFHPWIYS FGYELIIHST RLPLISGFYK LLSVTMKIAK RIKYFEGVSP RSLRRCPEDP
EKTSCFALFV KFGKEVAAKM KQYKDELLAS CLIFLLSLPH DIIMLDIKAY IPALQNAFKL
GLSCTPMADL GLDALEDWSA HIPRHMMQPY YKDVLPLLDG YLKSSTSTVE SQNNWEVRKL
SQAAQKGRSK VVIQRIRKAK TFSVDNSPSL EAVRTRVARL LGSLGGQINH NLITATSAEE
MMKKCVSWDT EKRLSFAVPF ADMKPVIYLD LFLPHVTELA LSASDRQTKV AACELLHGIV
TYMLGKASQM PEGRQGPPPM YHLHKRLFPV LLRLACDIDQ VTRQLYEPLV MQLIHWFTNN
KKFESQDTVA FLEAILSGIV DPVDSTLRDF CGQCIREFLK WSIKQTTPRQ QEESPANTKS
LFKRLYSLAL HPSAFKRLGA ALAFNSIYRE FREENSLVEQ FVFEALVVFL ESLALAHTDE
KSLGTAQQCC DAINHLKRIV KHKAPSLNKE GKRRVPRGFP ATKPVCLQDI VMWLLVQCGR
PQTECRHKAM ELFYEFVPLL PGNKSQSSWL ADTLKDRDVS FLISKFEGGG TDAKSPSGIL
SQPTLCGMQE PFSLQAVMQW MDMFLAALDC YNTFFELQMI KPYEVLGVNA SSMFLEAVRF
FLDTIALHDI HAAEQCFDCS SKGSMFSPQE RDMYNYSKCT IIVRIMEFVT VILETCQQDF
WKVLEKEMLN ASFIELVVMT VCDPSHIGFN TADVQVMKNL PDISVRLMKA LMKSPYQESL
KLCINKRITP QSLEDLCSVD LFNSEARLDQ VRFRAVLSAC KQLQKSGLLH SVLHSQDEGS
HFSLGSKLLS VVYKGIAPGG ERISLPSLDV SSKQLADSLL QLAFAIDEQC EELVSLLLNT
VVLSVPLSGA SQNHLMNFSH GQYFYSLFSE TINQQLLKNL DVAIVRLMES SVSNPQMVGS
ILNGMLDQSF RDRAVRKQQG AKLVTAVLRN WEKLDGWWAK GSSTESKMAV LTLLTKVLQI
DSSVSFNTNH EAFTAVFNTY TSLLTDQDLG LNLKGQAVII LPFFTNLTGE RLNDLKNALD
QLVAFNFPMR SDEFPKGTLK HNNYVDCTKK FLDALELSQS PMLLQLMTEI LCRDHRHFME
DLFQASFKRI SRRSTTDKQV MLLDTVHKMF RSEELLSNAA RQAFVDRSLL TLLWHCSLDA
LRVFFGKIIV EAMDTLNSRF TKSHEYTFDT QVTKKMGYYK LLEVMYVRLS KEEVYSKDSK
INQAYRGSMS VEGNELTKTL IKSCYDAFTE NMAGESQLLE KRRQYHCAAY NCAVAVISCV
FTESKFYQGF LFSEKSEKNL LIFENLIDLK RQYTFPVEIE VPLERKKRYI AIRKEARDAG
SNEPKYLASS SYMMGSSLSE EMSQFDFSTG VQGFSYSSQD ATGSSTRFRR KEPTEHKVLN
DEMELEMDEF NQHECMASMT TLIKHMQRNQ ITPKVEEGTV PVDLPLWMKF LHGKLGNPSV
PLNIRLFIAK LIVNTEDVFR PYAKHWLGPL LQLVVSGNNG GEGIHYMVVE IVVTILSWTS
VATPKGNIKD EILANRLLEF LMKNAFHPKR AVFRHNLEII KTVIECWKNC LSIPYSLIFE
KFSSGDPDTK DNSVGIQLLG IVLANNLPPF DPKCEIDRVR YFQALTSNMG LLKYREVYAA
AAEVLGLALQ YIDERENILE DPVYDCVIKQ LKHHQNTQHD KFIQCLNKVV KNFPPLADRF
MNAVFFLIPK LHGVMKTFCL EVIMCRAEEV PDLHLQLRSK DFIQIMNHRD DERQRVCLDI
VYKMLSKLKP LELKELLPGV TGFISHPSGI CRQRMYDILM WIYDNYSDPE SQADDDSREI
LQVTKEMLLQ GLIDENAELQ LIVRNFWSHE TRLPTNTLDR MLSLLSSLYS TKIETQYLSL
ITNFLLEMTS KSPDYSRKIF EHPLSECKFQ DFVVDSSWRY RSTVLTPMFV ETQASPSTHR
NLSQERSLSP SGSVGGQVRA TQRQYEFTPT QHGSGRSSFN WLTGSSIDTL AEYAVPSSSE
SLSSSMLLVS KRSEKFKQAT FKPLGPDFGK KRLGLPGDEV DSKTKGIEER AEILRLRRRF
LKDQDKLSLI YARKSLAEQK REKEMKSELK MKYDAQVTLY RSYRVGDLPD IQIEYCSLIA
PLQGLAQKDP TFAKQLFSSL FSGIFHEVKK SKSPSEKSTI VQKLLNDFNN FLSMSLSYFP
PFIACIQEMS YQHRELLELD SANVSTSCLA SLQQPVGILL LERALMALSP PEEPPSKRMR
GRTELPPDVI RWIELAKLYR SLGDYDALRG IFSGKIGTKE ITQKALLAEA RNDYAEAAQY
YDKALSQEDW QDGEPTEAEK DFWELASLEC YDHLTMWKSL EYCATVNIDS GKPPDLSKTW
NDPFFQETYL PYIIRSKLKL LLSGENDQTL LTFIDEAMKT EQKKAIIEMH YSQELSLLYI
LQDDFDRAKY YISNGMQIFM QSYSSIDSLL YQSRMTKLQS VQALTEIQDF INFMSKRSNL
ASEASLKRLL RTWTSRYPDA KLDPMNIWDD IITNRCFFLD KLQEKLPSDQ ANDSMEVDGE
YSAGDQMEVD QQSESIHSMI KSCKFNMKMK MIESARKQSS FAVAKKLLKD LRKEAKARED
WLLRWNYAYC RFTHSSSCSL SCPERLLSVL KTISLLEDAK SDYLSKNIMA FRNQNLLLGT
TYQIMANALS QDPRCLEQIE KEKAAKISLI SGESLESPKK VLAGLSKKAF QCFSCAVRKS
EEEVQSRSMD HVDVVGVVDA YMTLISFCDQ YLRREEEGLL EINTEDLQQF PAIVVEKMIK
ALKLNSREAR LRFPRLLQII ERYPAETLGL VTRELSSVPC WQFIGWISQM MALLDKDEAV
AVQHTIEEIA NTYPQALIYP FMISSESYCF KDTAAGCKNK EFVERIKNKL DRGGVVQDFV
RSLEQLSSPV MIFKDWAEDV KNELSKPQRN KKKLKEMYEG MYRNLGDLEA PGLGLMRKRF
IQAFGKDLDH HFGRGGSELL DMKTSDFNVI AASLYSKMNK SHKEPGNLKE CSPWMSEFKA
EFLRNELEVP GQYDGKGKPL PEYHAKISGF DERISVMESL RKPKRITIRG SDEQEYPFLV
KGGEDLRQDQ RIEQLFGVMN IILSQDATCS QRNMQIKTYQ VIPMTSRLGL IKWLENTCTL
KEFLRNSMSE EEDTSYYSPR GPRATYSEWL SRMGGKAQGI SRYLAMYRNA SRTEAVTSFK
GRESSVPEDL LRRAFVKMST SPQAFLALRS HFASSHALMC ISHWILGIGD RHLSNFMVNK
ETGGLVGIDF GYAFGAATQV FLSVPELMPF RLTRQFVNLM MPVKEWGLIY SVMVHALRAY
RSDPDLLIST MDVFVKEPSL DWKNFEQRQL KKGGTWIKEI DTTEVNWYPL QKVSYVRRKL
TGANPAIITC DELRLGHEKS PAYNDFAAVA RGNPNHDLRA KEPEDGLSEE TQVRCLIDQA
TDPNILGRVW EGWEPWM
//
