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Database: UniProt
Entry: U3JTI1_FICAL
LinkDB: U3JTI1_FICAL
Original site: U3JTI1_FICAL 
ID   U3JTI1_FICAL            Unreviewed;       432 AA.
AC   U3JTI1;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 56.
DE   RecName: Full=UDP-sugar transporter protein SLC35A5 {ECO:0000256|ARBA:ARBA00040377};
DE   AltName: Full=Solute carrier family 35 member A5 {ECO:0000256|ARBA:ARBA00041937};
GN   Name=SLC35A5 {ECO:0000313|Ensembl:ENSFALP00000006085.1};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000006085.1, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000006085.1, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000006085.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Probable UDP-sugar:UMP transmembrane antiporter involved in
CC       UDP-alpha-D-glucuronate/UDP-GlcA, UDP-GlcNAc/UDP-N-acetyl-alpha-D-
CC       glucosamine and UDP-N-acetyl-alpha-D-galactosamine/UDP-GalNAc transport
CC       from the cytosol to the lumen of the Golgi.
CC       {ECO:0000256|ARBA:ARBA00037779}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) = UDP-N-
CC         acetyl-alpha-D-galactosamine(out) + UMP(in); Xref=Rhea:RHEA:72735,
CC         ChEBI:CHEBI:57865, ChEBI:CHEBI:67138;
CC         Evidence={ECO:0000256|ARBA:ARBA00036186};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) = UDP-N-
CC         acetyl-alpha-D-glucosamine(out) + UMP(in); Xref=Rhea:RHEA:72695,
CC         ChEBI:CHEBI:57705, ChEBI:CHEBI:57865;
CC         Evidence={ECO:0000256|ARBA:ARBA00036522};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-alpha-D-glucuronate(in) + UMP(out) = UDP-alpha-D-
CC         glucuronate(out) + UMP(in); Xref=Rhea:RHEA:72727, ChEBI:CHEBI:57865,
CC         ChEBI:CHEBI:58052; Evidence={ECO:0000256|ARBA:ARBA00036726};
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC       subfamily. {ECO:0000256|ARBA:ARBA00009976}.
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DR   RefSeq; XP_005038624.1; XM_005038567.1.
DR   RefSeq; XP_005038625.1; XM_005038568.1.
DR   RefSeq; XP_016158218.1; XM_016302732.1.
DR   AlphaFoldDB; U3JTI1; -.
DR   STRING; 59894.ENSFALP00000006085; -.
DR   Ensembl; ENSFALT00000006112.2; ENSFALP00000006085.1; ENSFALG00000005838.2.
DR   GeneID; 101819331; -.
DR   KEGG; fab:101819331; -.
DR   CTD; 55032; -.
DR   eggNOG; KOG2234; Eukaryota.
DR   GeneTree; ENSGT00950000182827; -.
DR   HOGENOM; CLU_044353_0_0_1; -.
DR   OMA; SCLKWAV; -.
DR   OrthoDB; 5388606at2759; -.
DR   Proteomes; UP000016665; Chromosome 1.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   InterPro; IPR007271; Nuc_sug_transpt.
DR   NCBIfam; TIGR00803; nst; 1.
DR   PANTHER; PTHR10231; NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER; 1.
DR   PANTHER; PTHR10231:SF90; UDP-SUGAR TRANSPORTER PROTEIN SLC35A5-RELATED; 1.
DR   Pfam; PF04142; Nuc_sug_transp; 1.
DR   PIRSF; PIRSF005799; UDP-gal_transpt; 1.
DR   SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        20..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        49..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        99..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        150..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        278..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        306..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          406..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   432 AA;  48519 MW;  847DDC0C3A453F59 CRC64;
     MKLECSSRFA FCSKTTSQTL LLAGVFITLG SSRILLMKYS ANEDNKYDYL PATVNMCSEV
     VKLVLCVVLA LWKRNKEKGC MDNLSECFSW KNVCNSMKWS IPAFLYFLDN LIVFYVLSYL
     QPAMAVLFSN FVIITTALLF RIVLKRRLSW VQWASLVILF LSIVALTRGT GGHQHSLAAH
     GFHHNVFFRP SNHCLLATGP EEACVEKGNC AAPSFLRGFQ WNVTSTMAGA LKPLRLSLGH
     LLILVQCFVS ALANIYNEKM LKDVDQLGES IFTQNSKLYA FGVLFNGLML ALQAKDRRQI
     GNCGFFYGHN TFSIALIFVT AFLGLSVAFI LKFRDNMFHV MTAQINTVII TAVSFIVFDF
     RPSVEFFLEA PVVLLSIFIY NASKARGLEY AALRERGKII KGDAWERSSG DGEEFERLNK
     PSSDIDTDED SL
//
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