ID U3JTI1_FICAL Unreviewed; 432 AA.
AC U3JTI1;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=UDP-sugar transporter protein SLC35A5 {ECO:0000256|ARBA:ARBA00040377};
DE AltName: Full=Solute carrier family 35 member A5 {ECO:0000256|ARBA:ARBA00041937};
GN Name=SLC35A5 {ECO:0000313|Ensembl:ENSFALP00000006085.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000006085.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000006085.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000006085.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Probable UDP-sugar:UMP transmembrane antiporter involved in
CC UDP-alpha-D-glucuronate/UDP-GlcA, UDP-GlcNAc/UDP-N-acetyl-alpha-D-
CC glucosamine and UDP-N-acetyl-alpha-D-galactosamine/UDP-GalNAc transport
CC from the cytosol to the lumen of the Golgi.
CC {ECO:0000256|ARBA:ARBA00037779}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) = UDP-N-
CC acetyl-alpha-D-galactosamine(out) + UMP(in); Xref=Rhea:RHEA:72735,
CC ChEBI:CHEBI:57865, ChEBI:CHEBI:67138;
CC Evidence={ECO:0000256|ARBA:ARBA00036186};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) = UDP-N-
CC acetyl-alpha-D-glucosamine(out) + UMP(in); Xref=Rhea:RHEA:72695,
CC ChEBI:CHEBI:57705, ChEBI:CHEBI:57865;
CC Evidence={ECO:0000256|ARBA:ARBA00036522};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucuronate(in) + UMP(out) = UDP-alpha-D-
CC glucuronate(out) + UMP(in); Xref=Rhea:RHEA:72727, ChEBI:CHEBI:57865,
CC ChEBI:CHEBI:58052; Evidence={ECO:0000256|ARBA:ARBA00036726};
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000256|ARBA:ARBA00009976}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005038624.1; XM_005038567.1.
DR RefSeq; XP_005038625.1; XM_005038568.1.
DR RefSeq; XP_016158218.1; XM_016302732.1.
DR AlphaFoldDB; U3JTI1; -.
DR STRING; 59894.ENSFALP00000006085; -.
DR Ensembl; ENSFALT00000006112.2; ENSFALP00000006085.1; ENSFALG00000005838.2.
DR GeneID; 101819331; -.
DR KEGG; fab:101819331; -.
DR CTD; 55032; -.
DR eggNOG; KOG2234; Eukaryota.
DR GeneTree; ENSGT00950000182827; -.
DR HOGENOM; CLU_044353_0_0_1; -.
DR OMA; SCLKWAV; -.
DR OrthoDB; 5388606at2759; -.
DR Proteomes; UP000016665; Chromosome 1.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR NCBIfam; TIGR00803; nst; 1.
DR PANTHER; PTHR10231; NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER; 1.
DR PANTHER; PTHR10231:SF90; UDP-SUGAR TRANSPORTER PROTEIN SLC35A5-RELATED; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 49..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 406..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 432 AA; 48519 MW; 847DDC0C3A453F59 CRC64;
MKLECSSRFA FCSKTTSQTL LLAGVFITLG SSRILLMKYS ANEDNKYDYL PATVNMCSEV
VKLVLCVVLA LWKRNKEKGC MDNLSECFSW KNVCNSMKWS IPAFLYFLDN LIVFYVLSYL
QPAMAVLFSN FVIITTALLF RIVLKRRLSW VQWASLVILF LSIVALTRGT GGHQHSLAAH
GFHHNVFFRP SNHCLLATGP EEACVEKGNC AAPSFLRGFQ WNVTSTMAGA LKPLRLSLGH
LLILVQCFVS ALANIYNEKM LKDVDQLGES IFTQNSKLYA FGVLFNGLML ALQAKDRRQI
GNCGFFYGHN TFSIALIFVT AFLGLSVAFI LKFRDNMFHV MTAQINTVII TAVSFIVFDF
RPSVEFFLEA PVVLLSIFIY NASKARGLEY AALRERGKII KGDAWERSSG DGEEFERLNK
PSSDIDTDED SL
//