ID U3JTM7_FICAL Unreviewed; 1506 AA.
AC U3JTM7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Rho GTPase activating protein 5 {ECO:0000313|Ensembl:ENSFALP00000006131.1};
GN Name=ARHGAP5 {ECO:0000313|Ensembl:ENSFALP00000006131.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000006131.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000006131.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000006131.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_005047345.1; XM_005047288.2.
DR STRING; 59894.ENSFALP00000006131; -.
DR Ensembl; ENSFALT00000006158.2; ENSFALP00000006131.1; ENSFALG00000005883.2.
DR GeneID; 101813960; -.
DR KEGG; fab:101813960; -.
DR CTD; 394; -.
DR eggNOG; KOG4271; Eukaryota.
DR GeneTree; ENSGT00940000154553; -.
DR HOGENOM; CLU_004268_0_0_1; -.
DR OMA; MRNSFGG; -.
DR OrthoDB; 5405671at2759; -.
DR Proteomes; UP000016665; Chromosome 5.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0042169; F:SH2 domain binding; IEA:Ensembl.
DR GO; GO:0010631; P:epithelial cell migration; IEA:Ensembl.
DR GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
DR GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
DR GO; GO:0008361; P:regulation of cell size; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd22220; pseudoGTPaseD_p190RhoGAP-B; 1.
DR CDD; cd04373; RhoGAP_p190; 1.
DR Gene3D; 1.10.10.440; FF domain; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR002713; FF_domain.
DR InterPro; IPR036517; FF_domain_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039007; pG1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR032835; RhoGAP-FF1.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR045786; RhoGAP_pG1_pG2.
DR InterPro; IPR039006; RhoGAP_pG2.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR46005; RHO GTPASE-ACTIVATING PROTEIN 190; 1.
DR PANTHER; PTHR46005:SF2; RHO GTPASE-ACTIVATING PROTEIN 5; 1.
DR Pfam; PF01846; FF; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF16512; RhoGAP-FF1; 1.
DR Pfam; PF19518; RhoGAP_pG1_pG2; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00441; FF; 4.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF81698; FF domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51676; FF; 4.
DR PROSITE; PS51852; PG1; 1.
DR PROSITE; PS51853; PG2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 267..325
FT /note="FF"
FT /evidence="ECO:0000259|PROSITE:PS51676"
FT DOMAIN 366..420
FT /note="FF"
FT /evidence="ECO:0000259|PROSITE:PS51676"
FT DOMAIN 427..481
FT /note="FF"
FT /evidence="ECO:0000259|PROSITE:PS51676"
FT DOMAIN 482..548
FT /note="FF"
FT /evidence="ECO:0000259|PROSITE:PS51676"
FT DOMAIN 590..763
FT /note="PG1 pseudoGTPase"
FT /evidence="ECO:0000259|PROSITE:PS51852"
FT DOMAIN 779..944
FT /note="PG2 pseudoGTPase"
FT /evidence="ECO:0000259|PROSITE:PS51853"
FT DOMAIN 1265..1452
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 949..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1064..1091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1137..1158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1170..1253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1039
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1234..1251
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1506 AA; 172166 MW; 7B40D00D08B80ED5 CRC64;
MMAKNKEPRP PSYAVSVVGL SGTEKDKGNC GVGKSCLCNR FVRSKADEYY PEHTSVLSTI
DFGGRVVNND HFLYWGDVTQ SGEDGIECRI HVIEQTEFID DQTFLPHRST NLQPYIKRAA
ASKLQSAEKL MYICTDQLGL EQDFEQKQMP EGKLNIDGFL LCIDVSQGCN RKFDDQLKFV
NNLYIQLSKS KKPIIIAATK CDECVDHYLR EVQAFASNKK NLVVVETSAR FNVNVETCFT
ALVQMMDKTR GKPKIIPYLD AYKTQRQLVV TATDKFEKLV QTVRDYHATW KTVSNKLKNH
PDYEEYINLE GTKKAKNTFS KHIEQLKQEH IRKRKEEYIN ALPRALNTLL SNLDEIELLS
WSEALKVMEK RPDFQSCFVV LEKTPWDETD HIDKVNDRRI PFDLLNTLEA EKVYQNHVQH
LISEKRRVEM KEKFKKTLEK IQFISPGQPW EEVICFVVED EAFKYITDAD SKEVYGRHQR
EIVEKAKEEF QEMLFEHSEL FYDLDLNATP STDKMSEIHA VLSEEPRYKA LQKLAPDRES
LLLKHIGFVY HPTKETCLSG QNCMDIKVEE LLANSLLQLD HGRSNLYHDS ANIDKINLFI
LGKDGLAQEL ANEIRTQSTD DEYALDGKIY ELDLRPVDAK SPYLLTQLWT SAFKPHGCFC
VFNSIESLTF IGECIAKIRA EASQIRRDKY MANLSFTLIL ANQRDSVSKN LPILRHQGQQ
LANKLQCPFV DVPAGTYPRK FNEAQIKQAL RGVLEAVKHN FDVVSPVPTI KDLSEADLRI
VMCAMCGDPF SVDLILSPFL DSHSCSAAQA GHNNSLMLDK IIGEKRRRIQ ITILSYHSSI
GVRKDELVHG YILVYSAKRK ASMGMLRAFL SEVQDTIPVQ LVAVTDSQAD FFENEAIKEL
MTEGEHIATE ITAKFTALYS LSQYHRQTEV FTLFFSDVLE KKNMIESSYM SDSTRESTHT
SEDVFPRSPR GGSLDYNYPD SEDDAEGPPP YSPIGDDVRL LPAPSDRSKY RLDLEGNEYP
IHSTPVNCHD HERNHKVPPP IKPKPLVPRT NVKKLDPNLL KTIEAGIGKN PRKQPSRVPA
APPEDTDQSD NYAEPIDTIY KHKGFADDIY AVPEDSQNRI IKVRNSIVIN TQGEEENGFS
DRVSKSHGER RPSKYKYKSK TLFSKAKSYY RRTHSDASDD EAFTTSKTKG RKGRHRGSEE
DPLLSPVETW KGGIDNPAIT SDQELDDKKM KKKPHKVKED KKPKKKTKTF NPPIRRNWES
NYFGMPLQDL VTPEKPIPLF VEKCVQFIED TGLCTEGLYR VSGNKTDQDN IQKQFDQDHN
ICLESMGVTV NAVAGALKAF FADLPDPLVP YSLHQELLET SKIMDKTERL HELKEIVKKF
HPVNYDVFRY IITHLNRVSQ QYKTNFMTAD NLSICFWPTL MRPDFENREF LSTTKIHQSV
IETFIQQCQF FFYNGEIVEA PNPVACQPPP SNPVQMVEPM VPLQLPPPLQ PQLIQSQLPA
DPLGII
//
