ID   U3JVD6_FICAL            Unreviewed;       273 AA.
AC   U3JVD6;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   24-JAN-2024, entry version 54.
DE   SubName: Full=Cerberus 1, DAN family BMP antagonist {ECO:0000313|Ensembl:ENSFALP00000006740.2};
GN   Name=CER1 {ECO:0000313|Ensembl:ENSFALP00000006740.2};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000006740.2, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000006740.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|PIRNR:PIRNR027807}.
CC   -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872,
CC       ECO:0000256|PIRNR:PIRNR027807}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR   RefSeq; XP_005061708.1; XM_005061651.1.
DR   AlphaFoldDB; U3JVD6; -.
DR   Ensembl; ENSFALT00000006769.2; ENSFALP00000006740.2; ENSFALG00000006452.2.
DR   GeneID; 101816993; -.
DR   KEGG; fab:101816993; -.
DR   CTD; 9350; -.
DR   eggNOG; ENOG502S2G4; Eukaryota.
DR   GeneTree; ENSGT00530000063926; -.
DR   HOGENOM; CLU_104447_0_0_1; -.
DR   Proteomes; UP000016665; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0036122; F:BMP binding; IEA:Ensembl.
DR   GO; GO:0016015; F:morphogen activity; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0009948; P:anterior/posterior axis specification; IEA:Ensembl.
DR   GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
DR   GO; GO:0042074; P:cell migration involved in gastrulation; IEA:Ensembl.
DR   GO; GO:0071276; P:cellular response to cadmium ion; IEA:Ensembl.
DR   GO; GO:0048263; P:determination of dorsal identity; IEA:Ensembl.
DR   GO; GO:0003419; P:growth plate cartilage chondrocyte proliferation; IEA:Ensembl.
DR   GO; GO:0032926; P:negative regulation of activin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:2000381; P:negative regulation of mesoderm development; IEA:Ensembl.
DR   GO; GO:0007399; P:nervous system development; IEA:Ensembl.
DR   GO; GO:0035582; P:sequestering of BMP in extracellular matrix; IEA:Ensembl.
DR   GO; GO:0023019; P:signal transduction involved in regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0001657; P:ureteric bud development; IEA:Ensembl.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR016860; Cerberus.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR004133; DAN.
DR   PANTHER; PTHR15273:SF4; CERBERUS; 1.
DR   PANTHER; PTHR15273; DAN DOMAIN FAMILY MEMBER 5; 1.
DR   Pfam; PF03045; DAN; 1.
DR   PIRSF; PIRSF027807; Cerberus; 1.
DR   SMART; SM00041; CT; 1.
DR   PROSITE; PS01225; CTCK_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Secreted {ECO:0000256|PIRNR:PIRNR027807};
KW   Signal {ECO:0000256|PIRNR:PIRNR027807}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|PIRNR:PIRNR027807"
FT   CHAIN           20..273
FT                   /evidence="ECO:0000256|PIRNR:PIRNR027807"
FT                   /id="PRO_5033202434"
FT   DOMAIN          169..254
FT                   /note="CTCK"
FT                   /evidence="ECO:0000259|PROSITE:PS01225"
SQ   SEQUENCE   273 AA;  31370 MW;  4DF676B921252F56 CRC64;
     MSLLLLQILV LSCLGATELQ RTSQQRKSRR PFHHFLYVNK KLFESQSSPE LVSENPIVVE
     ETLKVPSFFV SIPQTASGSE KKEEKKMSRF ILPNAGLHVD QNPRTWVAPR EISPVENFSP
     PHHSNKRESE FPYRKDAKKF WDHFMLKKNS ASEEVVLPIK TNEMHQENCR TLPFAQGVTH
     NGCEKVIIQN NLCFGKCSSF HVPGSEDHLY TFCSHCLPSK FSMKRLDLNC TDSVPVVKEI
     MIVEECKCET RKIKDRVIGS LLSDLHENVH EHN
//