ID   U3JWF5_FICAL            Unreviewed;       526 AA.
AC   U3JWF5;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   SubName: Full=Beta-carotene oxygenase 1 {ECO:0000313|Ensembl:ENSFALP00000007109.1};
GN   Name=BCO1 {ECO:0000313|Ensembl:ENSFALP00000007109.1};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000007109.1, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000007109.1, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000007109.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|PIRSR:PIRSR604294-1};
CC       Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604294-1};
CC   -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC       {ECO:0000256|ARBA:ARBA00006787, ECO:0000256|RuleBase:RU003799}.
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DR   RefSeq; XP_005052413.1; XM_005052356.1.
DR   AlphaFoldDB; U3JWF5; -.
DR   STRING; 59894.ENSFALP00000007109; -.
DR   Ensembl; ENSFALT00000007140.2; ENSFALP00000007109.1; ENSFALG00000006810.2.
DR   GeneID; 101812113; -.
DR   KEGG; fab:101812113; -.
DR   CTD; 53630; -.
DR   eggNOG; KOG1285; Eukaryota.
DR   GeneTree; ENSGT00950000182913; -.
DR   HOGENOM; CLU_016472_1_1_1; -.
DR   OMA; MHTIGDS; -.
DR   OrthoDB; 294919at2759; -.
DR   Proteomes; UP000016665; Chromosome 11.
DR   GO; GO:0003834; F:beta-carotene 15,15'-dioxygenase activity; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:1901810; P:beta-carotene metabolic process; IEA:Ensembl.
DR   GO; GO:0016121; P:carotene catabolic process; IEA:Ensembl.
DR   GO; GO:0042574; P:retinal metabolic process; IEA:Ensembl.
DR   InterPro; IPR004294; Carotenoid_Oase.
DR   PANTHER; PTHR10543:SF132; BETA,BETA-CAROTENE 15,15'-DIOXYGENASE; 1.
DR   PANTHER; PTHR10543; BETA-CAROTENE DIOXYGENASE; 1.
DR   Pfam; PF03055; RPE65; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR604294-1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR604294-1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT   BINDING         172
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT   BINDING         236
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT   BINDING         307
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT   BINDING         512
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
SQ   SEQUENCE   526 AA;  60294 MW;  53088A9878C7B969 CRC64;
     MDALYGRNKE EHPDPIKAEV QGQLPTWLQG ILLRNGPGMH TIGDSKYNHW FDGMALLHSF
     TFKNGEVYYR SKYLRSDTYN CNIEANRIVV SEFGTMAYPD PCKNIFAKAF SYLSHTIPEF
     TDNCLINIMK AGDEFYATGE TNFIRKINAQ TLETLEKVDY NKYVAVNLAT SHPHYDSAGN
     VLNMGTSIVD KGKTKYLLFK IPSSVPEQEK KKSCFKHLEV VCSIPSRSLL HPSYYHSFGI
     TENYIIFIEQ PFRLDIVKMA TAYIRGVSWA SCLAYNKDDK TWFHFIDRKT KKEVSTKFYT
     DAMVFFHHIN AYEEDGHIVF DIIAYTDNSL YDMFYLKNLD KDFEENVKLT SIPTCKRFVV
     PLQHDKDAVV DSNLVTLPST ATAVKEKDGS IYCQPEILCE GIELPRINYD YNGKKYKYVF
     ATEVQWSPVP TKIAKFNTQT KEMLHWGQDN CWPSEPVFVP SPDAKEEDDG VILTCVVKTD
     PKDPPFLLVL DAKTFTELGR ATVNVEMHMD LHGMFIPQQD VKTGTE
//