ID U3JXV5_FICAL Unreviewed; 898 AA.
AC U3JXV5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Nuclear factor kappa B subunit 2 {ECO:0000313|Ensembl:ENSFALP00000007609.2};
GN Name=NFKB2 {ECO:0000313|Ensembl:ENSFALP00000007609.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000007609.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000007609.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000007609.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; U3JXV5; -.
DR STRING; 59894.ENSFALP00000007609; -.
DR Ensembl; ENSFALT00000007641.2; ENSFALP00000007609.2; ENSFALG00000007271.2.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000160968; -.
DR HOGENOM; CLU_004343_1_1_1; -.
DR Proteomes; UP000016665; Chromosome 6.
DR GO; GO:0033257; C:Bcl3/NF-kappaB2 complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0002268; P:follicular dendritic cell differentiation; IEA:Ensembl.
DR GO; GO:0002467; P:germinal center formation; IEA:Ensembl.
DR GO; GO:0038061; P:non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0048536; P:spleen development; IEA:Ensembl.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR CDD; cd07934; RHD-n_NFkB2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR030497; NFkB_p100_RHD_N.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169:SF21; NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT; 1.
DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 6.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 19..208
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REPEAT 461..493
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 500..532
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 533..554
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 571..603
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 605..638
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 639..671
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 379..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 148..175
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 393..407
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..725
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 898 AA; 97738 MW; 958A76EEBB913B13 CRC64;
MHFGFPMFLI GTSPFSSPVE GPYLVIIEQP KQRGFRFRYG CEGPSHGGLP GASSEKGRKT
YPTVKICNYT GVARIEVDLV THSDPPRVHA HSLVGKQCNE AGNCVTIVGP KDMTAQFSNL
GVLHVTKKNM MEIMKEKLKQ QKMRNRSQLL TEVELREIEQ EAKELKKVMD LSIVRLRFTA
YLRDSSGNFT LALQPVISDP IHDSKSPGAS NLKISRMDKT AGSVRGGDEV YLLCDKVQKD
DIEVRFYEDD ENGWQAFGDF SPTDVHKQYA IVFRTPPYHK PKIDRPVTVF LQLKRKRGGD
VSDPKQFTYY PVVEDKEEVE RKRKKVLPQF PQHFGGGSHM GGAGGGAGGF GSGGGGNLSF
PYSPGLTYSS IYSSGPHPVG SYQGGVQMKG SEAEGPRSDR QAPAEESTYC KELQKHAQLC
QLWMLALARR NAHALLDYSV TADPRMLLAV QRHLAASQDE NGDTPLHLAI IHEQTAVIKQ
LIDIIASIPS QQIINISNNL QQTPLHLAVI TKQPQVVQLL LQARADPTLL DRYGNSLLHL
ALQAGDEEML RTLLAHLGSA APYLLRLPNF HGLLPVHLAV KAKSLACLDL LVRTGADVNA
VERQSGRTPL HLAVEMENLN MATHLVKKLG ADINSRTFAG NTPLHLAAGL GSPTLTKLLL
KAGADVLCEN DEPMSLSSSE ASSDTDTDPE EQELAMDLGE PAPAAEHSSN SKLSTQGHWQ
AGHRQRQFQA LHTGALAGRA QAVREILLQA SQQGPEAELP TAPQPGEMGS LGSDWIELAK
RLGLCSLVET YKDTPSPSAS LLRSYELAGG SLGGLLEALD SMGLHNAVRM LHKTEALDKL
QSTELKEDSA YGSESVEEEQ APTLALKPGG ELPPSQQPQT LALKPGGELP PSQQPQVH
//
