ID U3JYK8_FICAL Unreviewed; 3198 AA.
AC U3JYK8;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=WDFY family member 4 {ECO:0000313|Ensembl:ENSFALP00000007862.2};
GN Name=WDFY4 {ECO:0000313|Ensembl:ENSFALP00000007862.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000007862.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000007862.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000007862.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 59894.ENSFALP00000007862; -.
DR Ensembl; ENSFALT00000007895.2; ENSFALP00000007862.2; ENSFALG00000007504.2.
DR Ensembl; ENSFALT00000029786.1; ENSFALP00000030862.1; ENSFALG00000007504.2.
DR eggNOG; KOG1786; Eukaryota.
DR eggNOG; KOG1788; Eukaryota.
DR GeneTree; ENSGT00940000155684; -.
DR HOGENOM; CLU_000175_5_2_1; -.
DR Proteomes; UP000016665; Chromosome 6.
DR GO; GO:0019882; P:antigen processing and presentation; IEA:Ensembl.
DR GO; GO:0036037; P:CD8-positive, alpha-beta T cell activation; IEA:Ensembl.
DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF3; WD REPEAT- AND FYVE DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2406..2531
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2548..2842
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2990..3031
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 3097..3121
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1954..1976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..819
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1958..1972
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3198 AA; 357203 MW; D966CD94592210D7 CRC64;
MKTWLMDKAA EHTWQLEDSP DGAGQQEQSP GDGDTAGVLE QPARSQEELP QSHSLLWETL
GKQFVEYEQM APFLIPEDQQ RRLLEFLPPF LKAWEQSAGA VVFPNIQLLA SEVSKLLTKE
IKRNLNGKPA EEARLALEQL LQQKGEAGDG HLLLKSVYLL SQTDLRTMWN IIGSGLPAAL
MQCLYLFFTV PLKKSSDDRE TSEDDAQTQE MLVQIMLNMY KEEQGVEELL AADKLHSLII
ATSSLWDQCS HSWKAPIGRV LRTISKAQTK SSIMHLQAVD CIKIAVQNLF TLADTLPACD
VCEAASIVLC FVKDSYPVSS ALLTEFENND GYQLLLKILL RCEGLQQNEG ASYLDEILDM
LTCLTTCGKT ELKVSGNIVH PQLPHFDFEQ TQTSGMTVKN LQPFQVLQSI FQRSNDQHLC
GRILAAIGTI WAWDRVNFFL LEWTLQPINQ FTDIIHFKPH PVQVQFFRLV ESIVLDLSYV
PHEILKKVQY LIKENIVPFC TLTALQCLLS MTQKDLLFSD IFRDSGLLGL LLALLRKEAK
ILRKSAGTDL PGLKEGPEKE LNVVMLKMVA ALTARSVRNT VVLKDYGMVP YVKIFLDDEC
YRSATLSILE QLSVISCEEY MSIIIGALCS STQWELHLKL DLLKSLLRIL ESPKSHSAFR
TCSGFNGLLS LLSDMEGALQ DPPSGQWAAV GQNCVLELVF YTLQGIAAAL HLDPVNSNFF
QRNGLFDKMA EDLGSLGCFW TEGKRQIHVS LENKRTFTEF WDAAFCSSEP FPAWLKNCIW
ILNFLDLMVK GTLHQESYFK ERKTEVGEES RDDQEASQAQ EEHPVTFKRL GNKLPASAYE
LWGSPEEKLE MRDCSIVHPG AVCVMVRLLP KLYREGHAQL SQEIQCAVVD HIQSLVKSEK
SRQVVCESGL LGTIVTSCQD AFCSDSHPLH LPLTRVFEKL ASQAVEPHVL RQFLWLGGSP
LLPSRPSANK TKVLSCQGSD SPNAGSEERV VDGKSDPQTV VPVRTSPCLS KGSALALQTA
MSLISMTSPR NFQLHSAALA PSFVEFDMSM EGYGCLYLPT LATVMGSSAD QSVSGGTGVG
SRMFPPSSGL TLSCWFLVSK FGLGHSSHPL RFLTVVRHMS RTEQEFVCFS VSFFPQDHSL
VISTEEVEFQ PLDIMEPEGE VLNPSPFPGQ VQFGCGKLLV TGQWHHLAVT VAKEAKKNCI
VSAYINGQMI GSAKMQYLQP LPGCSTSMEP SSFIDVYGYI ATPRIWKHKS SLTWRLGPTH
LFEEAISVET IEIIIKLGPQ YCSNFQAVQL PGEDQCSDQT IAPLVAEEKI SFGINAVCSS
LTTVQDIKSS FNEVDGRLIA KEMGINSRDS STPVFLAKNT AGHLSGSSRT IGSVAVGQYG
VRVFQSSPAA TSLNFVGGPA VLLGLIAMAR DDHTMYAAVK VLNSILNSSP LSGKLMRHIH
GYQLLSYLLK RKSRLLNNRI LQLIFSLVGT AELGFESSVI KNYSAFQYVL CNFELWMKAP
ENLDLALLSH LVEILQSSRD AHQNVAIAYQ VQMVPKLVFL FNDPEISSSK ITVACTILSH
LLQGYFNTRD VLRIGLFLVY TLKPSTVDEN QIYLDSVAER PTEALNQTSG KTICLRNQLL
KMLLDVIRSD KVHLSSEEKE KTFLALGPDW FLLFTQSYLH FSTVVLGIKL LLCFLQDRLL
LNKFKEGIVA GHWLENSSAG LNILMDNLKS HPPIPDNGYF LIFGFSVLQR CLTDHVHIPE
IYLVVAELFL AAPQSEPPEA VKKDLESMLQ WLLQNHLTEN VFKFGLCAEA AVLLLEMVRF
TVDKPVADAE ASWAIAYPGN VIEFLRLIYH SYTQDPMWHC PDFLKTLAVL AFHSEPPKGG
SEGLLTPDGP AIAEGKGCAD PSSLPLLPHP AKKQVWDFVR VLLMDSLLTI PANKQGHPLE
LLLEASPEGA SSEQKRLFQT KVLLSAMDVF QVASQGEGKT RPRGSSDPHG TSESAAPLPM
MNIAYFVQKL VEKLNSRMFA ADPKQILIFI AKQIMWVLES SASQKEVLLG ALYSCLNRAV
LYCLSRPQQS LPEQFNVLNT LIVLQEQWDI IFATYNSNSN FVICLMYCLC QLNSGSCSEG
FGVDAKPKLA SYHQIFLAPT EEEKGSLPTP DDVHQEILRA VEIIWKQLVS QRRQALEDTY
KMDLSVKGND KERDMKITEI TPLWEEIMAK AWQHLLVSEK KLLQNKAGPS TSQSKHNSWS
ESLSSAIRFI PGRNTKEMSC KSEGFVSCME RYRRVGQELY ASLYKDHLQM QQCAYSKAAK
DWMRLEEQLF CRGGPWRDAS GSLEPRWILD CYEGPSRMRR RIQHVNTQAA TMRTKSEVLL
ANIKETTSPT EVNPGELMLN GAEREMDQKG LDCNQLTFFP ALHESFHSED FLELCVERQI
ILQELVENEK VTFKCSVAVV QGHTALEGVL LFGKEHFYIC ECFVLSPLQE VYCTRHCLSR
ISDPFIFNLC HKDHAVGDQM CSRYSYHDIK EIHLMRFLLQ EIALEIFFKN GYSRFLVFHD
SDRNKIFKRF CSIQPALKSK GITEESLNIR KHSGGEKTML QKWQKREISN FDYLMYLNTL
AGRSYNDYMQ YPVFPWVLAD YHSETLNLTD PHTFRDLSKP MGAQTVERKQ KFIQRFNEVE
KSEGDLSAQC HYCTHYSSAI IVASYLVRME PFTQTFCSLQ GGSFDVADRM FHSVKSTWES
ASRDNMSDVR ELTPEFFYLP EFLTNANHFE LGCMQDGTVL GDVQLPPWAD GDPHKFILLH
RQALESDYVS AHLHRWIDLI FGHKQHGSAA VEAVNTYHPY FYGDKMDLNN IKDPLIKSTI
LGFISNFGQI PKQLFTKPHP SRNAQGKSSA GRETGLFLHS SGILPPLVSS LQNLKLSPVT
IKDYPKGAIG HIVHTEKGIL AVEKNKILIP PLWNKTFCWG FEDFTCCFGN YGSEKNVTTF
ECMADWGKCL CAVCPSATTI ITSGTSSVVC VWEFSLVKDK VKCLNLRQAL YGHTQAVTCL
AASVTYSIFV SGSDDRSCII WDLSQLTLIN QLPAHQESLR AVAINNSTGD ILSCAGSCLY
LWTVNGQLLA STSTACSPSC HIVCCCFAEV MDWDTRSIII TGSTDGVVRL WKMKYSSAPE
QGAGPRAQGG AAEEPGGAAG NKCGKHLVLC RELNPSAALA GKASRTSPAV TALAVSRNSS
KLLVGDDWGR LCCWSVDG
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