ID U3JYP0_FICAL Unreviewed; 496 AA.
AC U3JYP0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Sorting nexin-2 {ECO:0000256|ARBA:ARBA00020435};
GN Name=SNX2 {ECO:0000313|Ensembl:ENSFALP00000007894.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000007894.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000007894.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR AlphaFoldDB; U3JYP0; -.
DR STRING; 59894.ENSFALP00000007894; -.
DR Ensembl; ENSFALT00000007927.2; ENSFALP00000007894.2; ENSFALG00000007544.2.
DR eggNOG; KOG2273; Eukaryota.
DR GeneTree; ENSGT00940000155798; -.
DR HOGENOM; CLU_022783_2_1_1; -.
DR Proteomes; UP000016665; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0030904; C:retromer complex; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd07664; BAR_SNX2; 1.
DR CDD; cd07282; PX_SNX2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR037918; SNX2_PX.
DR InterPro; IPR005329; Sorting_nexin_N.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR10555; SORTING NEXIN; 1.
DR PANTHER; PTHR10555:SF31; SORTING NEXIN-2; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF03700; Sorting_nexin; 1.
DR Pfam; PF09325; Vps5; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 117..246
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 413..447
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 16..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 496 AA; 56137 MW; 766FF5933382F215 CRC64;
MLQPKCGYAD FDRSSPSSPE PASLPAEDLS TNSNGPKPAE IMLDGDREDL FAEATEEVSL
DSPERDPILS PESTPAVTPV TPTTLIAPRM ESKSVTAPVI FDRSREEIEE EANGDLFDIE
INVSDPEKVG DGMNAYMAYR VTTKTSLSIF HKTEFSVKRR FSDFLGLHSK LATKYMHIGY
IVPPAPEKSI VGMTKVKVGK EDSSSTEFVE KRRAALERYL QRTVKHPTLL QDPDLRQFLE
SSELPRAVNT QALSGAGILR MVNKAADAVN KMTIKMNESD AWFEEKQQQF ENLDQQLRKL
HSSVEALVCH RKELSANTAA FAKSAAMLGN SEDHTALSRA LSQLAEVEEK IDQLHQEQAF
ADFYVFSELL GDYIRLIAAV KGVFDHRMKC WQKWQDAQVT LQKKREAEAK LQLANKPDKL
QQAKDEIKEW ETKVQQGEKD FEQISKTIRK EVGRFEKERV KDFKTVIIEY LESLVQTQQQ
LIKYWEAFLP EAKAIA
//
