ID U3JZ15_FICAL Unreviewed; 475 AA.
AC U3JZ15;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=RasGEF domain family member 1C {ECO:0000313|Ensembl:ENSFALP00000008019.2};
GN Name=RASGEF1C {ECO:0000313|Ensembl:ENSFALP00000008019.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000008019.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000008019.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000008019.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; U3JZ15; -.
DR STRING; 59894.ENSFALP00000008019; -.
DR Ensembl; ENSFALT00000008052.2; ENSFALP00000008019.2; ENSFALG00000007687.2.
DR eggNOG; KOG3541; Eukaryota.
DR GeneTree; ENSGT00940000161005; -.
DR HOGENOM; CLU_022907_2_0_1; -.
DR OrthoDB; 7992at2759; -.
DR Proteomes; UP000016665; Chromosome 13.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF186; RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1C; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 37..167
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 207..455
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 475 AA; 54589 MW; 7D0B0BCBA5792592 CRC64;
MEGMPQTLSS TSMFTPCGFS PHLHTSKEGE QGGLIFQDGN LTSASLDALI QHLIPTTDYY
PEKAYIFTFL LSSRLFIEPH ELLSRVCHKC IEQQRLDDPV LDKARIRKFG PKILQLLTEW
TETFPYDFQE ERMIGHLKDM IHRIAPCDEA YWKKMNQLLQ ALNQKLATLS HGQEGIVKIS
TAVSDKLVAF KTKPPSIQRE ILSVCSDPYT LAQQLTHVEL ERLSHIGPEE FVQAFVHKDP
LDGTKTCFSE QKKTSNLEAY VKWFNRLCYL VATEICMPAK KKQRAQVIEF FIDVARECFN
IGNFNSLMAI ISGMNMSPVS RLKKTWSKVK TAKFFILEHQ MDPTGNFYNY RTALRGAAHR
SLTAHSNREK IVIPFFSLLI KDIYFLNEGC ANRLPNGHVN FEKFLELAKQ VGEFITWKQV
ECPFEQDPNI IHYLHTAPIF TEDGLYLASY ESESPENQTE KDRWKSLRST ILGKT
//
