ID   U3JZE1_FICAL            Unreviewed;       714 AA.
AC   U3JZE1;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=EEF1A lysine and N-terminal methyltransferase {ECO:0000313|Ensembl:ENSFALP00000008145.1};
GN   Name=METTL13 {ECO:0000313|Ensembl:ENSFALP00000008145.1};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000008145.1, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000008145.1, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000008145.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; U3JZE1; -.
DR   STRING; 59894.ENSFALP00000008145; -.
DR   Ensembl; ENSFALT00000008178.2; ENSFALP00000008145.1; ENSFALG00000007811.2.
DR   eggNOG; KOG2352; Eukaryota.
DR   GeneTree; ENSGT00510000047399; -.
DR   HOGENOM; CLU_010025_1_0_1; -.
DR   OMA; REIEWLF; -.
DR   Proteomes; UP000016665; Chromosome 8.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:Ensembl.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:1902807; P:negative regulation of cell cycle G1/S phase transition; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   CDD; cd02440; AdoMet_MTases; 2.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR   InterPro; IPR025714; Methyltranfer_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; NF037959; MFS_SpdSyn; 1.
DR   PANTHER; PTHR12176; SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN; 1.
DR   PANTHER; PTHR12176:SF88; SPERMINE_SPERMIDINE SYNTHASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G08500); 1.
DR   Pfam; PF13847; Methyltransf_31; 1.
DR   Pfam; PF01564; Spermine_synth; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          92..215
FT                   /note="Methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF13847"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          471..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          682..714
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        693..714
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   714 AA;  78264 MW;  0C7F4EBCBE877941 CRC64;
     MGSGRAAPRS RKRSAQGTRG AAAAAGAGHG PVRSGPVRCG AAMELLPRSP AEFSSARYWD
     RFFRQRGQRP FEWYGAFPEL CPVLYKYVRP RDKVLVVGCG NSELSEQMYD VGMCEDIINV
     DISDAVIRQM RERSAGTRPR MSYLLMDMLQ MDFPDSHFQV VLDKGTLDAL LTDEEEATLA
     KVDQMFAEIS RVLQVGGRYL CVSLAQAHVL KKAVEYFSQE GWVVRVHQVA SSGDKQQFVL
     PVFVYVMTKF RKIPGSAAQI LEICPEEQDK PMRVESAERL VAAVKDRQHY ALLCSQISKT
     PCREQVSLDL CDKESGKPRY TLHVVDSPSV KPSRDNHFAI FIIPQGRETE WLFGTEEGRR
     QLAASAGFGR LVTVALHREQ HYEGMASIQA ELSGKVMELA PPGLPARQQV PFLSVGGDIG
     VRAVRHCGNS PLSGDFVVED VRGDGTCYFR RLVFLQNRNV VQSEARLLAP TPFPGQKKRR
     KDKKKASPTE PAGAIDKSYL CCEHHKAMVA GLCLLGGPDA LPGELAVLVV GLGGGSLPLF
     VHDYFSQARV AVVEIDPSML EVATRWFGFS QGDRMQVHVS DGLDYVAKLA AEAPAQYDAI
     MFDVDSKDLT VGMSCPPPAF VEKPFLQKVK TILKPEGVFV LNLVCRDAGL KESVLAALRD
     VFPLLYGRSI QGEVNEILLC QAGPAGGRGP ADRKSVPPPP PPPPPPPPPP PPPP
//