ID U3JZY3_FICAL Unreviewed; 572 AA.
AC U3JZY3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=Cell division cycle 45 {ECO:0000313|Ensembl:ENSFALP00000008337.1};
GN Name=CDC45 {ECO:0000313|Ensembl:ENSFALP00000008337.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000008337.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000008337.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000008337.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CDC45 family.
CC {ECO:0000256|ARBA:ARBA00010727}.
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DR AlphaFoldDB; U3JZY3; -.
DR STRING; 59894.ENSFALP00000008337; -.
DR Ensembl; ENSFALT00000008373.2; ENSFALP00000008337.1; ENSFALG00000007995.2.
DR eggNOG; KOG2475; Eukaryota.
DR GeneTree; ENSGT00390000009662; -.
DR HOGENOM; CLU_005871_4_0_1; -.
DR OMA; MYLPRQL; -.
DR Proteomes; UP000016665; Chromosome 15.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0071162; C:CMG complex; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:Ensembl.
DR InterPro; IPR003874; CDC45.
DR PANTHER; PTHR10507; CDC45-RELATED PROTEIN; 1.
DR PANTHER; PTHR10507:SF0; CELL DIVISION CONTROL PROTEIN 45 HOMOLOG; 1.
DR Pfam; PF02724; CDC45; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 141..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..155
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 572 AA; 66245 MW; 9D771B794A8973CC CRC64;
MYSMYQHTLL GAYINAIILL FLQRVLLLVA SDVDALCACK ILQALFQCDH VQYTLVPVAG
WQELETAFLE HKDQFKYFVL INCGANVDLL EILQPEEDTF FFVCDSHRPI NVVNVYNDTQ
IKLLVKQDDD LDVPAYDDIF REEEDEEEDS EDEGDGSEPS EKRRRFEEEV IERTMNRRQR
REWEARRREI LFDYEQYEYH GTSSAMVMFD LAWIMSKDLN DMLWWAIVGL TDQWVQDKIT
QMKYVTDIGI LQRHVSRHNH RNEDEENSLS IDCMRIAFEY DLRLALYQHW SLYESLCNTS
YTSASLKLWS VQGQKRLQEF LADMGLPLKQ VKQKFNSMDV SLKENLREMI EESANKFGMK
DLRVQTFSIH FGFKNKFSAS DIVYATTSLM ENIEKEGHET TNFIKALDSL SRGNLDKLHQ
GLDLAKKQLR AIQQTVASCI CTNLVISQGP FLYCSLMEGT PDVKLFSKPV SLCLLSKYLL
KSFVCSTKNK RCKLLPLVMA APMDVEQGTV IMVGIPPETE SSDKKNFFGR AFEKAAESTN
SRTLHNHFEL SIIELKTEDR SKFLDALISL LS
//
