ID U3K0M9_FICAL Unreviewed; 442 AA.
AC U3K0M9;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Substance-P receptor {ECO:0000256|ARBA:ARBA00013755};
DE AltName: Full=NK-1 receptor {ECO:0000256|ARBA:ARBA00031678};
DE AltName: Full=Tachykinin receptor 1 {ECO:0000256|ARBA:ARBA00031714};
GN Name=TACR3 {ECO:0000313|Ensembl:ENSFALP00000008583.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000008583.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000008583.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000008583.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR RefSeq; XP_005044956.1; XM_005044899.1.
DR AlphaFoldDB; U3K0M9; -.
DR STRING; 59894.ENSFALP00000008583; -.
DR Ensembl; ENSFALT00000008621.2; ENSFALP00000008583.1; ENSFALG00000008232.2.
DR GeneID; 101816564; -.
DR KEGG; fab:101816564; -.
DR CTD; 6870; -.
DR eggNOG; KOG4219; Eukaryota.
DR GeneTree; ENSGT00940000153745; -.
DR HOGENOM; CLU_009579_6_1_1; -.
DR OMA; PQCLYSI; -.
DR OrthoDB; 2912851at2759; -.
DR Proteomes; UP000016665; Chromosome 4.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR GO; GO:0004995; F:tachykinin receptor activity; IEA:InterPro.
DR GO; GO:1902093; P:positive regulation of flagellated sperm motility; IEA:Ensembl.
DR CDD; cd16003; 7tmA_NKR_NK3R; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001681; Neurokn_rcpt.
DR InterPro; IPR000046; NK1_rcpt.
DR PANTHER; PTHR46925; G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED; 1.
DR PANTHER; PTHR46925:SF1; NEUROMEDIN-K RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01024; NEUROKININ1R.
DR PRINTS; PR00244; NEUROKININR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601681-50};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 61..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 78..332
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT DISULFID 134..209
FT /evidence="ECO:0000256|PIRSR:PIRSR601681-50"
SQ SEQUENCE 442 AA; 49708 MW; 3A2861042E3AF5E0 CRC64;
MTSVPTAKWN MSMSSRWNVS LAEAGDPWGQ ALEAPAANAS APVASSAGNF SNQFVQPSWR
IALWSLAYGG VVAVAVFGNL IVIWIILAHK RMRTVTNYFL VNLAFSDASM AAFNTLINFI
YALHSEWYFG EAYCRFHNFF PITAVFASIY SMTAIAVDRY MAIIDPLKPR LSATATKVVI
GSIWILAFLL AFPQCLYSIT KVMPGRTLCY VAWPGGPKQH FTYHVIVIVL VYCFPLLVMG
ITYSMVGVTL WGGEIPGDSS NKYHEQLKAK RKVVKMMIVV VLTFAVCWLP YHIYFIVTGI
YQQLNRWKYI QQIYLASFWL AMSSTMYNPI IYCCLNKRFR AGFKRAFRWC PFIEVSSYDE
LELKAARFHP TRQSSLYAVS RMDSSMTVVL DTSDGDSVHA SHKKRAAPRD LNFNGCSQRN
SRTVSTASSL ITSLHTSADA YS
//
