ID U3K159_FICAL Unreviewed; 1888 AA.
AC U3K159;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000008763.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000008763.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000008763.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR STRING; 59894.ENSFALP00000008763; -.
DR Ensembl; ENSFALT00000008801.2; ENSFALP00000008763.2; ENSFALG00000008409.2.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000154224; -.
DR HOGENOM; CLU_000540_5_0_1; -.
DR Proteomes; UP000016665; Chromosome 7.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR008051; Na_channel_a1su.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF280; SODIUM CHANNEL PROTEIN TYPE 1 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR PRINTS; PR01664; NACHANNEL1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1888
FT /note="Sodium channel protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5032881007"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 269..296
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 626..650
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 662..683
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 745..773
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 832..858
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1101..1119
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1140..1159
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1215..1243
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1341..1365
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1424..1442
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1454..1472
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1484..1504
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1541..1569
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1645..1668
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 1..303
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 432..584
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 634..863
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 872..1095
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1099..1374
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1423..1678
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 342..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1012..1041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1865..1888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 293..331
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 383..406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..497
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1871..1888
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1888 AA; 214662 MW; AF4131A2F18A7E17 CRC64;
MLIMCTILTN CVFMTMSNPP DWTKNVEYTF TGIYTFESLI KIIARGFCLE DFTFLRDPWN
WLDFTVITFA YVTEFVDLGN VSALRTFRVL RALKTISVIP GLKTIVGALI QSVKKLSDVM
ILTVFCLSVF ALIGLQLFMG NLRNKCLQWP PENFTLETNI TSQLNSSIGE NGTLVNSTVT
PFDWKGYIED ESHFYFLEGQ NDALLCGNSS DAGQCPEGYT CVKAGRNPNY GYTSFDTFSW
AFLSLFRLMT QDFWENLYQL TLRAAGKTYM IFFVLVIFLG SFYLINLILA VVAMAYEEQN
QATMEEAEQK EAEFQQMLEQ LKKQQEAAQS AAVAAAAVTA SAESREPSAG GEAGGLSESS
SDASKLSSKS AKERRNRRKK RKQKEQSGGE EKDEDEFHKS ESEDSIRRKG FRLSIEGNRL
TYEKKYSSPH QSLLSIRGSL FSPRRNSRTS LFSFRGRAKD VGSENDFADD EHSTFEDNDS
RRDSLFVPRR HGERRNSNIS QASRSSRMLA VFPVNGKMHS TVDCNGVVSL VGGPSVPTSP
VGQLLPEGTT TEPEMRKRIS GSFHVSMDFL EDPALRERAM SIASILTNTV EELEESRQKC
PPCWYKFANI FLIWDCSPHW LKVKHIVNLV VMDPFVDLAI TICIVLNTLF MAMEHYPMTD
EFNNVLSVGN LVFTGIFTAE MFLKIIAMDP YYYFQEGWNI FDGFIVTLSL VELGLADVEG
LSVLRSFRLL RVFKLAKSWP TLNMLIKIIG NSVGALGNLT LVLAIIVFIF AVVGMQLFGK
SYKECVCKIS SDCELPRWHM HDFFHSFLIV FRVLCGEWIE TMWDCMEVAG QAMCLIVFML
VMVIGNLVVL NLFLALLLSS FSADNLAVTD DDNEMNNLQI AVARMQKGID YVKRKVREFI
QKAFVRKQKV LDEIKPLEDL NNKKQKALDE IKPLEDLNNK NSCISNHTTV ELSKDHDYIK
DANGTTSGIG TGSSVEKYII DESDYMSFIN NPSLTVTVPI AVGESDFENL NTEEFSSESD
LEESKEKLNS SSSSEGSTVD IGLPAEEQPE AEPEEAQEPE ACFTEGCVRR FKCCQVSIEE
GRGKQWWNLR KTCFRIVEHN WFETFIVFMI LLSSGALAFE DIYIEQRKTI KTMLEYADKV
FTYIFILEML LKWVAYGYQT YFTNAWCWLD FLIVDVSLVS LTANALGYSE LGAIKSLRTL
RALRPLRALS RFEGMRVVVN ALLGAIPSIM NVLLVCLIFW LIFSIMGVNL FAGKFYYCVN
TTTDERFEVD QINNFSQCEE LIKNNQSARW KNVKVNFDNV GFGYLSLLQV ATFKGWMDIM
YAAIDSRDVL LQPKYEDNLY MYLYFVIFII FGSFFTLNLF IGVIIDNFNQ QKKKFGGQDI
FMTEEQKKYY NAMKKLGSKK PQKPIPRPGN KFQGMVFDFV TQQVFDISIM ILICLNMVTM
MVETDDQSEE MENILYWINL VFIVLFTGEC VLKLISLRHY YFTIGWNIFD FVVVILSIVG
MFLAEMIEKY FVSPTLFRVI RLARIGRILR LIKGAKGIRT LLFALMMSLP ALFNIGLLLF
LVMFIYAIFG MSNFAYVKRE AGIDDMFNFE TFGNSMICLF QITTSAGWDG LLAPILNSGE
PDCDPHKDHP GSSVKGDCGN PSVGIFFFVS YIIISFLVVV NMYIAVILEN FSVATEESAE
PLSEDDFEMF YEVWEKFDPD ATQFMEFEKL SDFAAALDPP LHLPKPNKVQ LIAMDLPMVS
GDRIHCLDIL FAFTKRVLGE SGEMDALRIQ MEDRFMAANP SKVSYEPITT TLKRKQEEVS
AVIIQRAYRR HLLKRTVKQA SFIYNKNKTE GGAGQGMKDE ILIDKLNENS FTEKTDITAS
TAVCPPSYDR VMRPVKEKHE KEDKDGQK
//
