ID U3K2F5_FICAL Unreviewed; 906 AA.
AC U3K2F5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=RNA binding motif protein 5 {ECO:0000313|Ensembl:ENSFALP00000009209.1};
GN Name=RBM5 {ECO:0000313|Ensembl:ENSFALP00000009209.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000009209.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000009209.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000009209.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RBM5/RBM10 family.
CC {ECO:0000256|ARBA:ARBA00009144}.
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DR RefSeq; XP_016156827.1; XM_016301341.1.
DR STRING; 59894.ENSFALP00000009209; -.
DR Ensembl; ENSFALT00000009248.2; ENSFALP00000009209.1; ENSFALG00000008828.2.
DR Ensembl; ENSFALT00000044226.1; ENSFALP00000017924.1; ENSFALG00000008828.2.
DR GeneID; 101808224; -.
DR KEGG; fab:101808224; -.
DR CTD; 10181; -.
DR eggNOG; KOG0154; Eukaryota.
DR GeneTree; ENSGT00940000156617; -.
DR HOGENOM; CLU_010527_0_0_1; -.
DR OMA; CESEHER; -.
DR OrthoDB; 298711at2759; -.
DR Proteomes; UP000016665; Chromosome 12.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003729; F:mRNA binding; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:Ensembl.
DR GO; GO:0000245; P:spliceosomal complex assembly; IEA:Ensembl.
DR CDD; cd12752; RRM1_RBM5; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 1.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR041591; OCRE.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034991; RBM5_RRM1.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR13948; RNA-BINDING PROTEIN; 1.
DR PANTHER; PTHR13948:SF21; RNA-BINDING PROTEIN 5; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF17780; OCRE; 1.
DR Pfam; PF00076; RRM_1; 2.
DR Pfam; PF00641; zf-RanBP; 1.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00360; RRM; 2.
DR SMART; SM00547; ZnF_RBZ; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS50102; RRM; 2.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022728};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00022728};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Spliceosome {ECO:0000256|ARBA:ARBA00022728};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT DOMAIN 191..271
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 274..303
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 324..408
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 738..768
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 834..880
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 906 AA; 104192 MW; 337EB9B7412C8FBF CRC64;
MGSDKRVSRT ERSGRYGSIV EREDRDERES RSRRRDDYKR SSEERRGDRY DDYRDYDSRD
YDSRDYDSRD SRDCRDYDSR DYDSRDSRVC RDYDSRDSRD CRDYDSRDCR DYDSRDSRDY
DCRDYDSRDC RDYDSRDSRD YDRDYDSRDY DSPERERERR NSDKSEDGYH SDGDYGEHDY
RNDINDEKES KTIMLRGLPI TVTENDIREL IESFEGPQPA DVRLMKRKTG VSRGFAFVEF
YHFQDATSWM EANQKKLVIQ GKQIAMHYSN PRPKFEDWLC NKCCLYNFRR RLKCFRCGAD
KFDSEQEVPP GAAEAVQSVD YYCDTIILRN IAPHTVVESI MTALSPYASL AVNNIRLIKD
KQTQQNRGFA FVQLSSAMDA SQLLQILQSL QPPLKIDGKT IGVDFAKSAR KDLLLPDGNR
VSAFSVASTA IAAAQWSSTQ PQTGEGSTLD YSYLQSGQDG YSQYAQYSQD YQQYYQNQGG
LLDTDTATIS GAPVTTTTAA VVSQSPQLYN QQTNSPDSPT QSAPPTTSTQ AQAAPPTGVV
PGTKYAVPDT STYQYDESSG YYYDPITGLY YDPNSQYYYN ALTQQYLYWD GEKETYMPAA
EGATYQQTAT TTTTKEVKEK KEKPKSKTAQ QIAKDMERWA KSLNKQKENF KNSFQPLSTR
EEERKESAAA DAGFALFEKK GALSERQQIL PEVLKNGDDE NPLKRGLVAA YSGDSDNDED
LLERMENEEE KLTDWKKMAC LLCRRQFPNK DALIRHQQLS DLHKQNMDIY RRSKLSEQEL
EALELREREM KYRDRAAERR EKYGIPEPPE PKRKKVYDAG TVNYEQPTKD GLDNSNIGNK
MLQAMGWREG SGLGRKCQGI TAPIEAQVRM RGAGLGAKGS SYGVSTADSY KDAVRKAMFA
RFTEME
//
