ID U3K488_FICAL Unreviewed; 1113 AA.
AC U3K488;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Rho GTPase activating protein 39 {ECO:0000313|Ensembl:ENSFALP00000009842.1};
GN Name=ARHGAP39 {ECO:0000313|Ensembl:ENSFALP00000009842.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000009842.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000009842.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000009842.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_016152402.1; XM_016296916.1.
DR AlphaFoldDB; U3K488; -.
DR STRING; 59894.ENSFALP00000009842; -.
DR Ensembl; ENSFALT00000009882.2; ENSFALP00000009842.1; ENSFALG00000009441.2.
DR GeneID; 101811437; -.
DR KEGG; fab:101811437; -.
DR CTD; 80728; -.
DR eggNOG; ENOG502QR6X; Eukaryota.
DR GeneTree; ENSGT00390000003161; -.
DR HOGENOM; CLU_005171_0_0_1; -.
DR OMA; FMEVSKW; -.
DR OrthoDB; 5480623at2759; -.
DR Proteomes; UP000016665; Chromosome 2.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04389; RhoGAP_KIAA1688; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR45876; FI04035P; 1.
DR PANTHER; PTHR45876:SF1; RHO GTPASE-ACTIVATING PROTEIN 39; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 50..84
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 721..873
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 920..1108
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 98..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1113 AA; 126641 MW; C838ACE6A60F981E CRC64;
MADEGMVGSL RGRRLEWVEI IEPRTRERMY ANLITGECVW DPPAGVRIKR TNENQWWELF
DPNTSRFYYY NATTQRTVWH RPQNCDIIPL AKLQTLKQNT ESPRASTENS PGRSSNVSRE
GSTSSSLEQE LEGNEKVQEQ RSSRQPSQYS VVKEETESSS PSGVFEKEYD IYRDYSTEGQ
LLHYRTSSLR WNAGTKERML IKVTDREPSF LLHQGNGYTP ENQPGSRSRR PSGGQQSPNL
QTFSSDADNS VFFPERKQSP FLKRAEHVGS CSPLLGRGDS FCSPLQAQHR KHSSESQPSS
PRYAYEPPLY EEPPMEYQAP IYDEPPVDMQ YEASGSYKAG SPQKSPIRKP HPFLQSPKQG
SNSPYQQLVL TKQKCPDRFM SLEYSPAGKE YVRQLVYVEQ SGSSPKMKTG LRHKYSPNPI
GGSYSLQHSP CLVRDQRLEI KSGDYSSMEG PDFCPGPTGA QVAQGEDSMS WSSQQDTLSS
TGYSPSTRKR KSRKPSVNHD ANASSTDGSG EREVLGELGE ERATPGPNRS PMNRTESKAA
EAEAARGFPE PFLAQARLAW EAQQAHYHMK QRSSWDSQKD GSGYESDGAL PLPMPGPVVR
AFSEDEALAQ QENKHWKRNT FEKLGFPQIL LEKSVSVQTN LASPEPYLHP SQSEDLGACA
QFENSRQTRN MMPSASCVFP TFNLRKPSSE TDIENWASKH FNKHTQGLFR RKVSIANMLA
WSSESIKKPM IMTNDRNVKK EACEIFKLIQ MYMGDRRAKT DQLNVALEIA TKGWSMQGLR
DELYIQLCRQ TTENFRYESL ARGWELMAIC LAFFPPTPKF HSYLEGYIYR HMDPVNDTKV
SRHLRHLLAR TNQKKPKLRK KPKPQSEEIP GVAISTYAKY CYNKLQKAAL TGAKKGLKKP
NIEEIRHAKN AVFNPSMFGS SLQDIVAMQK ERYPDRQLPW VQTRLSEEVL ALNGDQTEGI
FRVPGDIDEV NALKLQVDQW KIPTGLEDPH VPASLLKLWY RELEEPLIPH EFYEQCISHY
ENPEAAIAVV HSLPRINRMV LCYLIRFLQV FVQPANVAVT KMDVNNLAMV MAPNCLRCQS
DDPRIIFENT RKEMSFIRVL IQHLDTSFME GVL
//
