ID   U3K4I5_FICAL            Unreviewed;       734 AA.
AC   U3K4I5;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   24-JAN-2024, entry version 61.
DE   RecName: Full=RAS p21 protein activator 4 {ECO:0008006|Google:ProtNLM};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000009939.2, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000009939.2, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000009939.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; U3K4I5; -.
DR   STRING; 59894.ENSFALP00000009939; -.
DR   Ensembl; ENSFALT00000009979.2; ENSFALP00000009939.2; ENSFALG00000009533.2.
DR   eggNOG; KOG2059; Eukaryota.
DR   GeneTree; ENSGT00940000160149; -.
DR   HOGENOM; CLU_008096_0_0_1; -.
DR   OrthoDB; 24454at2759; -.
DR   Proteomes; UP000016665; Chromosome 19.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR001562; Znf_Btk_motif.
DR   PANTHER; PTHR10194:SF4; RAS GTPASE-ACTIVATING PROTEIN 4-RELATED; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF00779; BTK; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   PRINTS; PR00360; C2DOMAIN.
DR   SMART; SM00107; BTK; 1.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR   PROSITE; PS51113; ZF_BTK; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00432}.
FT   DOMAIN          44..160
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          232..440
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   DOMAIN          496..604
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
SQ   SEQUENCE   734 AA;  81482 MW;  40FCA39A31E141E5 CRC64;
     MDEDALSRDD IIGKVCITRD MLAEHPKGYS GWMSLSEVDP DEEVQGEIHL RVQVLGSQGS
     RRLRCSVLEA RDLARKDRNG ASDPFVRLRY NGKTQESTVV KKSCYPRWNE TFEFELAEPA
     GEKLCVEVWD WDLVGRNDFL GKVVFSIQGL EAAGQEEGWF RLWPDKSKPT EHERRGSLGS
     LQLQVKLRDE TVLPSHCYQP LVQLLCQEVK SGCQDGQVHL VTLLDETTTA ECRQEVAISL
     VKLFLGQGLV KEFLDLLFEL ELAKPCEPNT LFRSNSLASK SMESFLKVTG MPYLHFVLGP
     TISRVFDEKK YVELDPGKVE IKDVGCSGLH RVQTEGEVIE QGRQHLQSYL GELLDAIVRS
     APACPPLIRA AFRQLFQRVG ERFPQHQHAK FVAVTSFLCL RFFSPAVMSP KLFQLRDAHA
     DARTSRTLLL LAKAIQLVGN MEPAAGRAKE TWLSPLLPAL QQGTARMRDF ITRLVGTEED
     GGEEEGEGRP LGPPPAVVKE GLLLVHKTRG KGPLLAAAAG KKLHFCLTGE ALGFGKSPSA
     ERIGAIALGD ILAAEKVEEK SFGSSHVMQV VYTAPGGQQE TAYLQCKCVN ELNQWLSALR
     KVCGNNPRVL RSYHPGVFRG DKWSCCHQRD RTGLGCDRTR HGVTLQDWSD PLDPTVEAQR
     LFHHLQGLRG TLREKYWELL EPEDAQNGPR GEGRFGVGVL GVLLGMFWLG AVAGGAVGSQ
     CPCPLPQTLP CPRR
//