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Database: UniProt
Entry: U3K4V6_FICAL
LinkDB: U3K4V6_FICAL
Original site: U3K4V6_FICAL 
ID   U3K4V6_FICAL            Unreviewed;       304 AA.
AC   U3K4V6;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   24-JAN-2024, entry version 60.
DE   SubName: Full=Cysteine rich with EGF like domains 2 {ECO:0000313|Ensembl:ENSFALP00000010060.2};
GN   Name=CRELD2 {ECO:0000313|Ensembl:ENSFALP00000010060.2};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000010060.2, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000010060.2, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000010060.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CRELD family.
CC       {ECO:0000256|ARBA:ARBA00005897}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   AlphaFoldDB; U3K4V6; -.
DR   STRING; 59894.ENSFALP00000010060; -.
DR   Ensembl; ENSFALT00000010100.2; ENSFALP00000010060.2; ENSFALG00000009638.2.
DR   eggNOG; KOG4260; Eukaryota.
DR   GeneTree; ENSGT00940000160071; -.
DR   HOGENOM; CLU_038974_1_1_1; -.
DR   Proteomes; UP000016665; Chromosome 1A.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00064; FU; 1.
DR   Gene3D; 2.10.25.10; Laminin; 1.
DR   InterPro; IPR021852; DUF3456.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR002049; LE_dom.
DR   PANTHER; PTHR24039:SF28; FBN-1A.1; 1.
DR   PANTHER; PTHR24039; FIBRILLIN-RELATED; 1.
DR   Pfam; PF11938; DUF3456; 1.
DR   Pfam; PF07645; EGF_CA; 2.
DR   SMART; SM00181; EGF; 4.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00261; FU; 2.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS01248; EGF_LAM_1; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          103..145
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          256..295
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DISULFID        135..144
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   304 AA;  33066 MW;  403B4D8CBD22A2AB CRC64;
     SRLVALAAFG LLSDTAKKNF GGGNTAWEEK TLSKYESSEI RLVEIIENLC DSSNFECNNM
     VEEHEELIEK WWFKLKKKYP DLFKWFCIET IEVCCPAGTY GPDCLACHGG SERPCHGNGH
     CDGDGTRGGD GSCSCKKEYT GQFCLDCSSG YFSSLRNETH SVCTACHASC KTCTGSSNKD
     CQDCKEGWIK NEGGACVDLD ECAASPCKDH QYCLNTDGSF SCKACDASCV GCTGEGSEKC
     KTCASGYMKE DEKCTDIDEC NLPEKVCTKE NQDCVNTSGS YKCVCSEGFE DKDGTCVQTV
     KPGK
//
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