ID   U3K610_FICAL            Unreviewed;      1057 AA.
AC   U3K610;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=DIS3-like exonuclease 1 {ECO:0000256|ARBA:ARBA00016366};
DE            EC=3.1.13.1 {ECO:0000256|ARBA:ARBA00012163};
GN   Name=DIS3L {ECO:0000313|Ensembl:ENSFALP00000010464.1};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000010464.1, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000010464.1, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000010464.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC         nucleoside 5'-phosphates.; EC=3.1.13.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001849};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC       {ECO:0000256|ARBA:ARBA00005785, ECO:0000256|RuleBase:RU003901}.
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DR   RefSeq; XP_005051754.1; XM_005051697.2.
DR   AlphaFoldDB; U3K610; -.
DR   STRING; 59894.ENSFALP00000010464; -.
DR   Ensembl; ENSFALT00000010506.2; ENSFALP00000010464.1; ENSFALG00000010033.2.
DR   GeneID; 101810482; -.
DR   KEGG; fab:101810482; -.
DR   CTD; 115752; -.
DR   eggNOG; KOG2102; Eukaryota.
DR   GeneTree; ENSGT00530000063106; -.
DR   HOGENOM; CLU_002333_5_0_1; -.
DR   OMA; LPLHEWK; -.
DR   OrthoDB; 945235at2759; -.
DR   Proteomes; UP000016665; Chromosome 10.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:Ensembl.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0008859; F:exoribonuclease II activity; IEA:Ensembl.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:Ensembl.
DR   GO; GO:0016075; P:rRNA catabolic process; IEA:Ensembl.
DR   CDD; cd09862; PIN_Rrp44-like; 1.
DR   Gene3D; 2.40.50.690; -; 1.
DR   Gene3D; 2.40.50.700; -; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR041505; Dis3_CSD2.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR033771; Rrp44_CSD1.
DR   InterPro; IPR033770; RRP44_S1.
DR   PANTHER; PTHR23355:SF30; DIS3-LIKE EXONUCLEASE 1; 1.
DR   PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR   Pfam; PF17849; OB_Dis3; 1.
DR   Pfam; PF00773; RNB; 1.
DR   Pfam; PF17216; Rrp44_CSD1; 1.
DR   Pfam; PF17215; Rrp44_S1; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022722};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          467..819
FT                   /note="Ribonuclease II/R"
FT                   /evidence="ECO:0000259|SMART:SM00955"
FT   COILED          995..1026
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1057 AA;  120170 MW;  F4C5126EFFC2D8BF CRC64;
     MLRTEKVLQL RGQQGRAVRV VREHYLRPDV PCCSALCRSA QCRAACARDG KLLSDDVTHY
     VVPDCKVVQE YLEILEFPEL KGIIFMQTAC QAVQHQKGRR QYNKLRNLLK DPRHDCTVFA
     NEFHQHCYLP REKGESMEKW QTRNIYNAAA WYHNHCLGQM PVVMVTEDED AIRQYGNETE
     GVFVISFKNY LDNFWPDLKA AHELFDSIVQ ARRERESESQ ENHGKEYPEH LPVEILEAGI
     KSGRYLQGTL NVNKHRAQLE AFVRLQGFGS KNTELQSDIL IYGAKARNRA IHGDVVVVEL
     LPVHEWKGRT VALCENETED KAPADTTGDP MPTGKVVGII QKNWRDYVVT FPSKEESQSQ
     GRNAQKVLVT PWDYRIPKIR ISTQQAEALQ EYRVVVRIDS WESTSLYPNG HFVRVLGRIG
     DLEGEIAAIL VENSICAAPF SEIQMSEMPV SSPKNPWKVS PEEAKKRLDL RDTHLIFSID
     PKGCEDVDDA LSVRTLPNGN LELGVHIADV THFVAANSYT DVEARARATT YYLADRRYDM
     LPAVLSADLC SLLSGVDRYA VSVLWELEKE SFETLRVQYS RTLIRSAYKL EYETAQALLD
     GDTSVVGDIV ELQSLDEGTR QKKLAELVWA ISKLTDIARH VRAKRDRCGA LELEGIEIRV
     QLDDRRNIHD LIPKQPLEVH ETVAECMILA NHWVAKRISE DFPHQALLRQ HPPPRQEFFT
     ELRECASAKG FSIDTRSNKA LAESLDRAND PSDPIVNKLL RSMATHAMSN ALYFSTGSCP
     EEQFHHYGLA LEKYTHFTSP IRRYADIIVH RLLMAASLRG TTGDVKDNII SNKDLEELCR
     HINNRNRAAQ RAQKQSTELF QCMYFRDRSA ESDERCVADG VIYSIRTNGV LVFVPRYGIK
     GAAYMKNKEG LVISCQGAGS CQWKPGSLHR SQHKITSTTT TGDSVTLSLF DHITVRILVQ
     SSRCHAESIK LEIIRNAPHH TADTEAAHRS SHVVRSDLVK EVSQYAEEAQ RAQERARVEV
     MDEESREFCQ TKGPSLYQLL EEIRELALLD VTEDIRT
//