ID U3K6L1_FICAL Unreviewed; 636 AA.
AC U3K6L1;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=Pendrin {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Sodium-independent chloride/iodide transporter {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 4 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A4 {ECO:0000313|Ensembl:ENSFALP00000010665.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000010665.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000010665.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000010665.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Sodium-independent transporter of chloride and iodide.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR AlphaFoldDB; U3K6L1; -.
DR STRING; 59894.ENSFALP00000010665; -.
DR Ensembl; ENSFALT00000010707.2; ENSFALP00000010665.1; ENSFALG00000010232.2.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01070000253775; -.
DR HOGENOM; CLU_003182_9_4_1; -.
DR OMA; WKQNKTD; -.
DR Proteomes; UP000016665; Chromosome 1A.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814:SF33; PENDRIN; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 43..68
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 125..142
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 154..173
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 201..220
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 241..263
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 305..322
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 337..367
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 391..585
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 613..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 636 AA; 69768 MW; 96ADF3E9601B1D47 CRC64;
MVGSVVLSMA PDENFLIEGS NATGINGTGA LIDTESRDAE RVLIASTLTF LVGILQVIFG
VLQIGFIVRY LADPLVGGFT TAAAFQVLVS QLKIVLNVST KNYNGVLSII YTLVETFEKI
GTTNIADLIA GLLTIFVCMV VKEINDRFKH KIPIPIPIEV IVTIVATGIS YAADLEKKYN
AGIVKSIPRG FLPPAPPNVS LFSQMIAASF SIAIVAYAIA VSVGKVYATK YDYAIDGNQE
FIAFGLSNIF SGAFSCFVAT TALSRTAVQE STGGKTQVAG IISAGIVLIS IVALGKLLEP
LQKSVLAAVV IANLKGMFMQ VFDVPRLWRQ NKVDAMIWVF TCIASIILGL DLGLLAGLLF
GLLTVVLRVQ FPSWGGFGNI PGTDIYKKVK DYKNVIEPEG VKILKFSSPI FYANIDGLKS
SLKSTVGFDA VKVYNKRLKA LRKIQKLIKK GKLKATKNGI ISEPGINNEA FETDEEPEDN
QDLQVPTKEV EIQVDWNSEL PVKVNIPKVP IHSLILDFGA VTFLDIVAVR SIKTIIKEFE
RIDVRVYFAS YQDNLISQLE RGAFFDDTVR KDIFFLTVHD AVLYIRNQMT YSDNQDPIFE
KISLMQESKE PIEFTEASQP DDELDVQEEA MRRLAS
//