ID   U3K7C6_FICAL            Unreviewed;       481 AA.
AC   U3K7C6;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Patatin like phospholipase domain containing 2 {ECO:0000313|Ensembl:ENSFALP00000010930.1};
GN   Name=PNPLA2 {ECO:0000313|Ensembl:ENSFALP00000010930.1};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000010930.1, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000010930.1, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000010930.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_005046917.1; XM_005046860.1.
DR   AlphaFoldDB; U3K7C6; -.
DR   STRING; 59894.ENSFALP00000010930; -.
DR   Ensembl; ENSFALT00000010974.2; ENSFALP00000010930.1; ENSFALG00000010479.2.
DR   GeneID; 101805858; -.
DR   KEGG; fab:101805858; -.
DR   CTD; 57104; -.
DR   eggNOG; KOG3773; Eukaryota.
DR   GeneTree; ENSGT00940000160155; -.
DR   HOGENOM; CLU_018371_0_1_1; -.
DR   OMA; TKWEEYQ; -.
DR   OrthoDB; 5395310at2759; -.
DR   Proteomes; UP000016665; Chromosome 5.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0051265; F:diolein transacylation activity; IEA:Ensembl.
DR   GO; GO:0051264; F:mono-olein transacylation activity; IEA:Ensembl.
DR   GO; GO:0004623; F:phospholipase A2 activity; IEA:Ensembl.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:Ensembl.
DR   GO; GO:0006651; P:diacylglycerol biosynthetic process; IEA:Ensembl.
DR   GO; GO:1905691; P:lipid droplet disassembly; IEA:Ensembl.
DR   GO; GO:0019915; P:lipid storage; IEA:Ensembl.
DR   GO; GO:0010891; P:negative regulation of sequestering of triglyceride; IEA:Ensembl.
DR   GO; GO:0010898; P:positive regulation of triglyceride catabolic process; IEA:Ensembl.
DR   GO; GO:0019433; P:triglyceride catabolic process; IEA:Ensembl.
DR   CDD; cd07220; Pat_PNPLA2; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR033562; PLPL.
DR   InterPro; IPR033903; PNPLA2.
DR   InterPro; IPR002641; PNPLA_dom.
DR   PANTHER; PTHR12406; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED; 1.
DR   PANTHER; PTHR12406:SF29; PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT   DOMAIN          10..179
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
SQ   SEQUENCE   481 AA;  53507 MW;  FBACB9AC949AECEE CRC64;
     MFPLDSTWNI SFAGCGFLGV YHIGVASCLQ EHAPFLVANA KKVYGASAGA LTATALVSGA
     CLGEAGASII RVSKEARKRF LGPLHPSFNL VKTIRMSLSK MVPDNGHEVA AGRLGISLTR
     VSDGENVILS DFNSKEELIQ ACICSTFIPV YCGLIPPTLR GVRYVDGGIS DNLPQYELKN
     TITVSPFSGE SDICPRDSST NMHELRVTNT SIQFNLRNLY RLSKALFPPE PQVLRDMCKQ
     GYRDALHFLK KNGLLHRPSP ARPLLAIEAP PGEKKEEETE AEDQLEDNTA LAVVEEHIFE
     HLPPRLNQAL LEACAERRSF LTGLSNMLPV RVATAMMVPY MLPLESAVSF TVRLLEWLPD
     IPEDIRWMRE QMTDICSYLV KKAKKKLGSH LSARLYYHLE LGGPQKLPIS PPPPCGEALP
     MWIRSNRSVS DVMMKWEEYQ RQLMLGLLCI NVDMQASLFP REGFQLKLPP LDCAKECLPL
     F
//