ID U3K8U4_FICAL Unreviewed; 713 AA.
AC U3K8U4;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000011448.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000011448.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000011448.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the kindlin family.
CC {ECO:0000256|ARBA:ARBA00008052}.
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DR AlphaFoldDB; U3K8U4; -.
DR STRING; 59894.ENSFALP00000011448; -.
DR Ensembl; ENSFALT00000011494.2; ENSFALP00000011448.2; ENSFALG00000010970.2.
DR eggNOG; KOG3727; Eukaryota.
DR GeneTree; ENSGT00390000013444; -.
DR HOGENOM; CLU_011611_0_0_1; -.
DR OrthoDB; 5399911at2759; -.
DR Proteomes; UP000016665; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13205; FERM_C_fermitin; 1.
DR CDD; cd01237; PH_fermitin; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR037843; Kindlin/fermitin.
DR InterPro; IPR040790; Kindlin_2_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037837; PH_Kindlin/fermitin.
DR PANTHER; PTHR16160; FERMITIN 2-RELATED; 1.
DR PANTHER; PTHR16160:SF12; FERMITIN FAMILY HOMOLOG 1; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF18124; Kindlin_2_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 413..509
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 183..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 713 AA; 81140 MW; 1F354FB270CDAA79 CRC64;
MMLRLWRNAF VSESGGEPCC LVGWFAFAGL TQTFPKMVSS TEYGSHTWEL SLTVDHQHEG
VQKEQVLHVT GDLHVGGLML KLVEKIKIAQ DWSDYAFWWE QKKCWLLKTH WTLDKYGVQA
DAKLIFTAQH KMLRLRLPNM KTVRLKVSFS SMVFRAVSDI CKILNIRRSE ELSLLKQSEG
TLKKKKKKDK NSKEPATEDI LNLSNSPVSS GLPANAGLYS KTMTPVYDPV SGSPASSTIT
WFSDGSLTEQ NCSILALSYS TCSPEMLAEM YQPRTLADKA KLNAGWLDSS RSLMEQGVGE
EDLLLLRFKY YTFFDLNPKY DAVRINQLYE QARWAILLEE IDCTEEEMLI FAALQYHVSK
LSLSSETQDS ICEAEVDEVE AALSNLEVTL EGGNKSNILE DITDIPKLAD NLKLVRPKKL
ALKAIKTYWF VFRDTSISYF KNKESAQGEP VEKLNLKGCE VVPDVNVAAK KFGIKLLIPV
ADGMNEVYLR CDNEDQYARW MAACVLASKG KTMADSSYQL EVQKILSFLQ MKNWTMSSQA
ASEPENVDMK PECFVSPRYT KKFKSKQLIA RILEAHQNVS QMSLVEAKLR FIQAWQSLPE
FGLSYYVVRF KGSKKDDVLG VSYNRLIRID MATGDPITTW RFSNMKQWNV NWEIRQVAIE
FDQNVSIAFT CLSADCKIIH EYIGGYIFLS TRSKDHNETL DEELFHKLTG GQE
//
