ID U3K9H2_FICAL Unreviewed; 1156 AA.
AC U3K9H2;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=DNA helicase MCM9 {ECO:0000256|ARBA:ARBA00041085};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=Minichromosome maintenance 9 {ECO:0000256|ARBA:ARBA00042301};
GN Name=MCM9 {ECO:0000313|Ensembl:ENSFALP00000011676.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000011676.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000011676.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000011676.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC ECO:0000256|RuleBase:RU004070}.
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DR RefSeq; XP_005043568.1; XM_005043511.1.
DR AlphaFoldDB; U3K9H2; -.
DR STRING; 59894.ENSFALP00000011676; -.
DR Ensembl; ENSFALT00000011724.2; ENSFALP00000011676.1; ENSFALG00000011180.2.
DR GeneID; 101812818; -.
DR KEGG; fab:101812818; -.
DR CTD; 254394; -.
DR eggNOG; KOG0477; Eukaryota.
DR GeneTree; ENSGT01050000244824; -.
DR HOGENOM; CLU_000995_7_2_1; -.
DR OMA; RTEEHNC; -.
DR OrthoDB; 1342948at2759; -.
DR Proteomes; UP000016665; Chromosome 3.
DR GO; GO:0097362; C:MCM8-MCM9 complex; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0032406; F:MutLbeta complex binding; IEA:Ensembl.
DR GO; GO:0032407; F:MutSalpha complex binding; IEA:Ensembl.
DR GO; GO:0032408; F:MutSbeta complex binding; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0007292; P:female gamete generation; IEA:Ensembl.
DR GO; GO:0070716; P:mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication; IEA:Ensembl.
DR GO; GO:0071168; P:protein localization to chromatin; IEA:Ensembl.
DR GO; GO:0036298; P:recombinational interstrand cross-link repair; IEA:Ensembl.
DR CDD; cd17760; MCM9; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF48; DNA HELICASE MCM9; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 304..507
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 660..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 919..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1003..1115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..786
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..822
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..845
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1021
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1056
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1156 AA; 127940 MW; F846EF7CA9461AE4 CRC64;
MGLSAEQVSL IGQVFESYVL EHHRDDILSI LREPDEQAHY PVVVDALTLF EANMEIGEYL
NAFPGQVLPV LDSALRRAAL AALQDSADPA RLSLKQNLHA RVSGLPVCPE LTREHIPKSK
DVGHFLSVTG TVIRTSSVKV LEFERSYICN KCKHVFVVKA DFEQYYTFCR PAACLNEEGC
NSTKFMCLSG TTSSPTCCRD YQEIKIQEQV QRLSVGSIPR CMVVVLEDDL VDSCKSGDDI
TVYGVVMQRW KPFREGTRCD LELVLKANYI KVNNEQLAGV VIDEEVRKEF EDFWERHKND
PLAGRNEILA SLCPQVFGLY LVKLAVAMVL AGGVQRTDAA GTRTRGESHL LLVGDPGTGK
SQFLKYAVKI MPRSVLTAGI GSTSAGLTVT AVKEFGEWNL EAGALVLADG GLCCIDEFNS
IKEHDRTSIH EAMEQQTISV AKAGLVCKLS TRTTILAATN PKGHYDPNES VSVNIALGSP
LLSRFDLVLV LLDTKNEEWD HIISSFILQN KDCPSKSEKL WSMERMKTYF CLIKSIQPKL
SDESNLILVR YYQMQRQSDC RNAARTTVRL LESLIRLAEA HARLMFRDTV TLEDAVTVVS
VMESSMQGGA LLGGINALHT SFPENPMEQY RTQCEIILER LELKDLLHKE LRRLDRLQKE
NSCQQQPEET NFSATTRCSN EDALGQSKQR SQSEPSNQEE YNSGPQTPFL EGSWEGNIHL
EPLCNPKCGN SKNTNSLSWF DSVEGSSIDP GENSLRKSPV PKIPPNNLAS KTSSSEERSA
SIPRKQNGES LAAVDLNAPL KQKDKVSKLR RKRTEEHNCS SSEDNTADPA PSSSVQDSVI
RQHASRSWQR LHREKSYGFF TSTQDPEAKA LPSELPASDL LDLSSNEDSV LGEGNSVSVA
ARSTAVSIRK RSKDQVVKET RLVSSPEQES ENPPAAKLAK FSFRPKTKLA YSSEKTNEEF
SLFPSGTFCK LGEQLQREQL PEECCPPEKS KMTLPRLGKC SLEKGSIDNK EEEEQQSRAL
GKEIRESATI CSDGRSDAVS PPPTEKGREG EEKLGGASTG KVRSSTLAKL STFSFVSRPE
AKSDTSPAIR NDTSRESHSP SLKVHVSNPS KRKSFALGNS STATVVTKTS LFSIAELDDA
ALDFDWDKEV RKNPSM
//
