ID U3K9U2_FICAL Unreviewed; 568 AA.
AC U3K9U2;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Heat shock transcription factor 2 {ECO:0000313|Ensembl:ENSFALP00000011796.1};
GN Name=HSF2 {ECO:0000313|Ensembl:ENSFALP00000011796.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000011796.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000011796.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000011796.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HSF family. {ECO:0000256|ARBA:ARBA00006403,
CC ECO:0000256|RuleBase:RU004020}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; U3K9U2; -.
DR STRING; 59894.ENSFALP00000011796; -.
DR Ensembl; ENSFALT00000011844.2; ENSFALP00000011796.1; ENSFALG00000011294.2.
DR eggNOG; KOG0627; Eukaryota.
DR GeneTree; ENSGT00940000155906; -.
DR OMA; GKQCGID; -.
DR Proteomes; UP000016665; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0001162; F:RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR010542; Vert_HSTF_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015:SF185; HEAT SHOCK FACTOR PROTEIN 2; 1.
DR PANTHER; PTHR10015; HEAT SHOCK TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR Pfam; PF06546; Vert_HS_TF; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00434; HSF_DOMAIN; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 62..86
FT /note="HSF-type DNA-binding"
FT /evidence="ECO:0000259|PROSITE:PS00434"
FT REGION 271..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 63113 MW; 0B44EE3D4094DE09 CRC64;
APPPPQPPQQ PSPPFASPGV PAFLSKLWAL LGETPSNQLI TWSQNGKSFL VLDEQRFAKE
ILPKYFKHNN MASFVRQLNM YGFRKVVHVD SGIVKLERDG PVEFRHAYFR QGREDLLEHI
KRKVSSSRPE ENKIRQEDLS KIICSAQKVQ IKQTTIESQL SLLKRENESL WREVSELRAK
HLQQQQVIRK IVQFIVTLVQ NNQLVSLKRK RPLLLNTNGP TKSNVFQKIV KEPADSSHHV
PLNRNEGLKQ REQISDDIVI YDVTEDVVEE GHPMADEENL PVTPETSEDT TSDSSNCSCS
YHSPDIVIVE DDNEDEYAPV IQGDKSTESV AVPGNDPVSP VSDSTSPLMS SAVQLNNQST
LTAEDPVSVM DSILNENGVI SQNINLLGKV ELLDYLDSID CSLEDFQAML SGRQFSIDPD
LLVDLFTSSV QMNPTDHDHI TNTKTETKGK ETNKNNAGPA ASQETQGNKP RSDKQLIHYT
AFPLLAFLDG SPGSAVESGG FTAEAPSTVE KSLEGDELLE SSLDPQPTQS KLVRLEPLTE
AEASEATLFY LCELAPAPMD TDMSFLDN
//
