ID U3KB61_FICAL Unreviewed; 545 AA.
AC U3KB61;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Amino acid transporter {ECO:0000256|RuleBase:RU361216};
GN Name=LOC101810269 {ECO:0000313|Ensembl:ENSFALP00000012265.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000012265.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000012265.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000012265.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361216}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361216}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000256|RuleBase:RU361216}.
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DR RefSeq; XP_016159962.1; XM_016304476.1.
DR AlphaFoldDB; U3KB61; -.
DR STRING; 59894.ENSFALP00000012265; -.
DR Ensembl; ENSFALT00000012315.2; ENSFALP00000012265.1; ENSFALG00000011740.2.
DR GeneID; 101810269; -.
DR KEGG; fab:101810269; -.
DR eggNOG; KOG3787; Eukaryota.
DR GeneTree; ENSGT00940000164644; -.
DR HOGENOM; CLU_019375_3_2_1; -.
DR OMA; RKLGWYG; -.
DR OrthoDB; 49426at2759; -.
DR Proteomes; UP000016665; Chromosome 28.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:1902475; P:L-alpha-amino acid transmembrane transport; IEA:UniProt.
DR Gene3D; 1.10.3860.10; Sodium:dicarboxylate symporter; 1.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR11958:SF102; AMINO ACID TRANSPORTER; 1.
DR PANTHER; PTHR11958; SODIUM/DICARBOXYLATE SYMPORTER-RELATED; 1.
DR Pfam; PF00375; SDF; 1.
DR PRINTS; PR00173; EDTRNSPORT.
DR SUPFAM; SSF118215; Proton glutamate symport protein; 1.
DR PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361216};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|RuleBase:RU361216};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361216};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361216};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361216}.
FT TRANSMEM 33..54
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 75..94
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 109..128
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 273..294
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 306..332
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT TRANSMEM 344..369
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361216"
FT REGION 497..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 545 AA; 59327 MW; 5DA9934CE6D16432 CRC64;
MWEWVRRVVL HSLCKALLRL WKWVGAFWYK NGLLTLSMLS VVTGCLLGFL LRTLELTDLE
KQYFSFPGEL LMRMLKMLIL PLITSSLMSG LATMDSRACG KMGVITITYY LWTTFMAVTV
GIILVVSIHP GAAAQKDNYS VGKVVLSSAD ALLDLIRNMF PSNLVEASFQ QYRTVLVPVV
KSPGFPKIPG KPVNFIYFAP DDKNPEIHRP VFLELTPSPE MTYRTLAGTS NEMNVLGIVI
FSATIGLLLG KMGERGAPLV NVCQCLNEAV MKIVSMAVWY FPFGIVFLIA GKILEMEDPS
VTGQKLGLYV ITVVSGLALH GIILLPLLFV LITKKNPFAF IQGILQALLI ALATSSSSAT
LPITLKCLLE NNGIDRRVAR FVLPVGATIN MDGTALYEAV AAIFIAQVNE YELDLGQIIT
ISITASAASI GAAGIPQSGL VTMVIVLTSV GLPTEDITLI IAVDWALDRL RTMTNVLGDA
LAAGIIAHIC EKDFAPKPPP QDPVSNKDKF PSAETSQLHP KVNGIETTED TLLDQTGIHY
NICQV
//
