ID U3KBD4_FICAL Unreviewed; 1916 AA.
AC U3KBD4;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Myosin heavy chain 1 {ECO:0008006|Google:ProtNLM};
GN Name=LOC101807400 {ECO:0000313|Ensembl:ENSFALP00000012338.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000012338.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000012338.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000012338.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 59894.ENSFALP00000012338; -.
DR Ensembl; ENSFALT00000012388.2; ENSFALP00000012338.2; ENSFALG00000004991.2.
DR eggNOG; KOG0161; Eukaryota.
DR GeneTree; ENSGT00940000161336; -.
DR HOGENOM; CLU_000192_8_1_1; -.
DR Proteomes; UP000016665; Chromosome 18.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF74; MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 34..83
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 87..787
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 630..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..686
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 851..1812
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1841..1903
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 180..187
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1916 AA; 219789 MW; DD17BAFAAAA92CEE CRC64;
AMSTDAEMAI FGEAAPYLRK SEKERIEAQN KPFDAKTSVF VVHAKESYVK GKIESKDAGK
VTVKTEGGET LTVKEDQIFS MNPPKYDKIE DMAMMTHLHE PAVLYNLKER YAAWMIYTYS
GLFCVTVNPY KWLPVYNPEV VLAYRGKKRQ EAPPHIFSIS DNAYQFMLTD RENQSILITG
ESGAGKTVNT KRVIQYFATI AASGEKKKEE KLNAWPGTLE DQIISANPLL EAFGNAKTVR
NDNSSRFGKF IRIHFGATGK LASADIETYL LEKSRVTFQL KAERSYHIFY QIMSNKKPEL
IDMLLITTNP YDYQFVSQGE ITVPSINDQE ELMATDSAID ILGFTADERT AIYKLTGAVM
HYGNLKFKQK QREEQAEPDG TEVADKAAYL MGLNSADLLK ALCYPRVKVG NEYVTKGQTV
QQVYNSVGAL AKAVYEKMFL WMVVRINEQL DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC
INFTNEKLQQ FFNHHMFVLE QEEYKKEGIE WEFIDFGMDL AACIELIEKP MGIFSILEEE
CMFPKATDTS FKNKLYDQHL GKSNNFQKPK PGKGKAEAHF SLVHYAGTVD YNITGWLEKN
KDPLNETVIG LYQKSSVKTL ALLFASAGGE AEASGGGGGG GGKKGGKKKG SSFQTVSALF
RENLNKLMTN LRSTHPHFVR CIIPNETKTP GAMEHELVLH QLRCNGVLEG IRICRKGFPS
RVLYADFKQR YKVLNASAIP EGQFIDSKKA SEKLLGSIDV DHTQYRFGHT KVFFKAGLIG
LLEEMRDEKL AQLITRTQAL CRGFLMRVEY RRMVERRESI FCIQYNIRSF MNVKHWPWMK
LFFKIKPLLK SAESEKEMAN MKGEFEKTKE ELAKSEAKRK ELEEKMVSLL KEKNDLQLQV
QAEADSLADA EERCDQLIKT KIQLEAKIKE VTERAEDEEE INAELTAKKR KLEDECSELK
KDIDDLELTL AKVEKEKHAT ENKVKNLTEE MAALDETIAK LTKEKKALQE AHQQTLDDLQ
AEEDKVNTLT KAKTKLEQQV DDLEGSLEQE KKLRMDLERA KRKLEGDLKL AQDSIMDLEN
DKQQLDEKLK KKDFEISQIQ SKIEDEQALG MQFQKKIKEL QARIEELEEE IEAERTSRAK
AEKHRADLSR ELEAISERLE EAGGATAAQI EMNKKREAEF QKMRRDLEEA TLQHEATAAA
LRKKHADSTA ELGEQIDNLQ RVKQKLEKEK SEMKMEIDDL ASNMESVSKA KANLEKMCRT
LEDQLSEIKT KEEEHQRMIN DLNAQRARLQ TEAGEYSRQV DEKDALVSQL SRGKQAFTQQ
IEELKRHLEE EIKAKSALAH ALQSARHDCD LLREQYEEEQ EAKGELQRAL SKANSEVAQW
RTKYETDAIQ RTEELEEAKK KLAQRLQDAE EHVEAVNAKC ASLEKTKQRL QNEVEDLMID
VERSNAACAA LDKKQKNFDK ILAEWKQKYE ETQAELEASQ KESRSLSTEL FKMKNAYEES
LDHLETMKRE NKNLQQEISD LTEQIAEQGK AIHELEKVKK QVEQEKSDIQ AALEEAEASL
EHEEGKILRL QLELNQVKSE IDRKIAEKDE EIDQMKRNHL RIVDSMQSTL DAEIRSRNEA
LRLKKKMEGD LNEMEIQLSH ANRMAAEAQK NLRNTQAVLK DTQIHLDEAL RTQDDLKEQV
AMVERRANLL QAEVEELRAA LEQTERSRKL AEQELLDASE RVQLLHTQNT SLINTKKKLE
TDIAQIQSEM EDTIQEARNA EEKAKKAITD AAMMAEELKK EQDTSAHLER MKKNLDQTVK
DLQHRLEEAE QLALKGGKKQ LQKLEARVGR AGASEEDRKN VLRLQDLVDK LQMKVKSYKR
QAEEAEELSN VNLSKFRKIQ HELEEAEERA DIAESQVNKL RVKSREFHSK KIGEEE
//
