ID   U3KBH3_FICAL            Unreviewed;       869 AA.
AC   U3KBH3;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   24-JAN-2024, entry version 60.
DE   SubName: Full=Sorting nexin 25 {ECO:0000313|Ensembl:ENSFALP00000012377.2};
GN   Name=SNX25 {ECO:0000313|Ensembl:ENSFALP00000012377.2};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000012377.2, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000012377.2, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000012377.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   STRING; 59894.ENSFALP00000012377; -.
DR   Ensembl; ENSFALT00000012427.2; ENSFALP00000012377.2; ENSFALG00000011857.2.
DR   Ensembl; ENSFALT00000030643.1; ENSFALP00000032805.1; ENSFALG00000011857.2.
DR   eggNOG; KOG2101; Eukaryota.
DR   GeneTree; ENSGT00950000182856; -.
DR   HOGENOM; CLU_005899_0_1_1; -.
DR   OrthoDB; 5392990at2759; -.
DR   Proteomes; UP000016665; Chromosome 4.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   CDD; cd06878; PX_SNX25; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037899; SNX25_PX.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF29; SORTING NEXIN-25; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT   DOMAIN          28..194
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          320..434
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          539..659
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   REGION          687..707
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          476..527
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   869 AA;  100813 MW;  927E4ACF77090CDA CRC64;
     MIYVLFEFQS NWSGSSHDSI QSRRVIISHN MDKALKEVFD YSYRDYILSW YGQLSRDEGQ
     LYQLLSEDFW EIAKQLRQRL SHIDVVKVVC NDVVKALLSH FCDLKGANAR QEDPPRPFLL
     HSYLKSADEE VRFLQKCSQV LVYCLLPSKD VQSVSLRIVL AEILATKVLK PVVELLSDPD
     YINRMLLSQL EYREQMNEHQ KKDYTYAPSY EEFIKLINSS SDVEFLKQLR YQIVVEIVQA
     TTISNIPQVK RQKDSKGKET AAMKADLLRA RNVKRYINQL TVAKKQCEKR IRLLGGPAYD
     QQEDGISDEG DGPPGQKILQ FEEILANPSY REHFRIYMER MDKMALIGLW ESVENLKNAN
     KAEIPQLVSE IYQNFFVESR EIPVEKSLYK EIQQSLVGNK GIEVFYRIQA DVYETLKDRY
     YPSFIVSDLY ERSVKKEEER SSAQLTPEDK DEVSQGCEEA TEECSTRINE QASYAVNKLR
     QLNDKLEYKK QALNSICNSP KPDKKIVSKL KDEITLMERE HSDLQLHIAR TDWWCENLGM
     WKAFIVSGEV LEENGEQVPC YSVMVSLQEV GGAETKNWTV PRKLNEFQNL HRKLSECFPS
     LKKVQLPSLS KLPFKSIDQK FMEKSKNQLN NFLQKLLSDE RLCQSEALYA FLSPSPEHLK
     VIDVQGKKSS FSLSSFLERL PGDLFSHQEE ETEEDSDLSD YGEEVDGKKD SLAEPCFMLI
     GEIFELRGMF KWVRKTLIAL VQVTFGRTIN KQIRDTVHWM FSEPMLVYYI GVFRDAFWPN
     GKLAPPPRAK SDEQKQETKQ RAQQKLLENI PDTLQNLVGQ QNARHGVVKV FNALQERKAN
     KHLLYVLLEL LLTELCPELR AHLEQLNAT
//