ID U3KBL5_FICAL Unreviewed; 1695 AA.
AC U3KBL5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Myosin VA {ECO:0000313|Ensembl:ENSFALP00000012419.2};
GN Name=MYO5A {ECO:0000313|Ensembl:ENSFALP00000012419.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000012419.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000012419.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000012419.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 59894.ENSFALP00000012419; -.
DR Ensembl; ENSFALT00000012469.2; ENSFALP00000012419.2; ENSFALG00000011894.2.
DR eggNOG; KOG0160; Eukaryota.
DR GeneTree; ENSGT00940000155347; -.
DR HOGENOM; CLU_000192_9_2_1; -.
DR Proteomes; UP000016665; Chromosome 10.
DR GO; GO:0005884; C:actin filament; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0032433; C:filopodium tip; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0042470; C:melanosome; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0005777; C:peroxisome; IEA:Ensembl.
DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0006892; P:post-Golgi vesicle-mediated transport; IEA:Ensembl.
DR GO; GO:0030050; P:vesicle transport along actin filament; IEA:Ensembl.
DR CDD; cd15478; Myo5a_CBD; 1.
DR CDD; cd01380; MYSc_Myo5; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 3.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR037988; Myo5a_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR036103; MYSc_Myo5.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF273; UNCONVENTIONAL MYOSIN-VA; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00612; IQ; 5.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00015; IQ; 6.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50096; IQ; 6.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 1..632
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1374..1650
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT REGION 469..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..534
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 975..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 784..967
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1190..1279
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1695 AA; 196975 MW; 3E27297D7F9A0BD9 CRC64;
MGDMDPHIFA VAEEAYKQMA RDERNQSIIV SGESGAGKTV SAKYAMRYFA TVSGSASEAN
VEEKVLASNP IMESIGNAKT TRNDNSSRFG KYIEIGFDKR YRIIGANMRT YLLEKSRVVF
QAEEERNYHI FYQLCASAAL PEFKTLRLGN ANYFHYTKQG GSPVIDGVDD AKEMVNTRQA
CTLLGISDSY QMGIFRILAG ILHLGNVEFA SRDSDSCTVP PKHEPLTIFC DLMGVEYEEM
AHWLCHRKLA TATETYIKPI SKLHAINARD ALAKHIYANL FNWIVDHVNK ALHATVKQHS
FIGVLDIYGF ETFEINSFEQ FCINYANEKL QQQFNMHVFK LEQEEYMKEQ IPWTLIDFYD
NQPCINLIEA KMGVLDLLDE ECKMPKGSDD SWAQKLYNTH LNKCALFEKP RMSNKAFIIK
HFADKVEYQC EGFLEKNKDT VYEEQIKVLK SSKFKLLLEL FQDEEKVLSP TSATPSGRVP
LSRTPIKPAK ARPGQASKEH KKTVGHQFRN SLHLLMETLN ATTPHYVRCI KPNDFKFPFT
FDEKRAVQQL RACGVLETIR ISAAGFPSRW TYQEFFSRYR VLMKQKDVLG DRKQTCKNVL
EKLIQDKDKY QFGKTKIFFR AGQVAYLEKI RADKLRAACI RIQKTIRGWL MRKKYMRMRK
AAITIQRHVR GYQARCYATF LRRTRAATTI QKFQRMYVVR KRYQRMREAT IALQALLRGY
MVRNKYQMML REHKCVVLQK HVRGWLARRR YRRTLRAVVY LQCCYRRMMA KRELKKLKIE
ARSVERYKKL HIGLENKIMQ LQRKIDEQNK EYKSLLEKMS SLELTYSTET EKLRSDVERL
RTSEEEARSA TSRVLSLQEE IAKLRRELQH TQAEKRSIEE RADKYKHETE QLVSELKEQN
SLLKTEKEEL NRRIHDQAKE ITESMEKKLV EETKQLELDL NDERLRYQNL LNEFSRLEER
YDDLKDEMNL MVSIPKPGHK RTDSTHSSNE SEYTFSSEIT EAEDLPLRME QEPSEKKAAL
DMSLFLKLQK RVSELEQEKQ SLQDELDRKE EQALRAKAKE EERPPIRGAE LEYESLKRQE
LESENKKLKN ELNELQKALT ETRAPEVTAP GAPAYRVLLD QLTSVSEELE VRKEEVLILR
SQLVSQKEAI QPKHTMTDAT ILLEDVQKMK DKGEIAQAYI GLKETNRLLE SQLQSQKKSH
ENELESLRGE IQSLKEENNR QQQLLAQNLQ LPPEARIEAS LQHEITRLTN ENLDLMEQLE
KQDKTVRKLK KQLKVFAKKI GELEVGQMEN ISPGQIIDEP IRPVNIPRKE KDFQGMLEYK
KEDEQKLVKN LILELKPRGV AVNLIPGLPA YILFMCVRHA DYLNDDQKVR SLLTSTINGI
KKVLKKRGDD FETVSFWLSN TCRFLHCLKQ YSGEEGFMKH NTPRQNEHCL TNFDLAEYRQ
VLSDLAIQIY QQLVRVLENI LQPMIVSGML EHETIQGVSG VKPTGLRKRT SSIADEGTYT
LDSIIRQLNS FHSVMCQHGM DPELIKQVVK QMFYIIGAIT LNNLLLRKDM CSWSKGMQIR
YNVSQLEEWL RDKNLMNSGA KETLEPLIQA AQLLQVKKKT DEDAEAICSM CNALTTAQIV
KVLNLYTPVN EFEERVLVSF IRTIQVRLRD RKDSPQLLMD AKHIFPVTFP FNPSSLALET
IQIPASLGLG FISRV
//
