ID U3KDG0_FICAL Unreviewed; 755 AA.
AC U3KDG0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=Amyloid beta precursor protein binding family A member 2 {ECO:0000313|Ensembl:ENSFALP00000013064.1};
GN Name=APBA2 {ECO:0000313|Ensembl:ENSFALP00000013064.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000013064.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000013064.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000013064.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_005052074.1; XM_005052017.2.
DR RefSeq; XP_016156496.1; XM_016301010.1.
DR AlphaFoldDB; U3KDG0; -.
DR STRING; 59894.ENSFALP00000013064; -.
DR Ensembl; ENSFALT00000013118.2; ENSFALP00000013064.1; ENSFALG00000012520.2.
DR GeneID; 101817026; -.
DR KEGG; fab:101817026; -.
DR CTD; 321; -.
DR eggNOG; KOG3605; Eukaryota.
DR GeneTree; ENSGT00940000158943; -.
DR HOGENOM; CLU_013563_3_0_1; -.
DR OMA; MSPEHSG; -.
DR OrthoDB; 2881953at2759; -.
DR Proteomes; UP000016665; Chromosome 10.
DR CDD; cd00992; PDZ_signaling; 2.
DR CDD; cd01208; PTB_X11; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR12345:SF12; AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2; 1.
DR PANTHER; PTHR12345; SYNTENIN RELATED; 1.
DR Pfam; PF00595; PDZ; 2.
DR Pfam; PF00640; PID; 1.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 2.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 374..561
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 574..659
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 665..741
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..95
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 755 AA; 84022 MW; 4E895D15F0FA4739 CRC64;
MANRKHQSIT ASMLDHRARA CPTSSHNREP QNEESDLPIE DYAEKEAELA TVRPGSPTPV
EHECNDHSGD GDSSSDYVNN TSEEEDYDEG LPEEEEGITY YIRYCPEDDS YLEGMDCNGE
EYAPHEEHHV ETDDCQEAVE EWAEGKIQHQ DENEVMDRQE WQEGQDNGIQ ILEDEASSLE
IQDQEENIQY CQSEGDYPDY YPAEANGNSQ GISPYHSRKE DAELEEQEED IDQIVAEIKM
SMSMSSINST TEMSPEHSGT ENMAHDYKET CSKGEAVHSA NRHEGRPKSL NIPSASKHSG
DVHRGFKAKS RSPEDRQKWP QEQMCNGLEQ PRKQQRSDLN GPADNNNPPE TKKVSSFPSF
VDVPGPCEPE DLIDGIIFAA NYLGSTQLLS ERNPSKNIRM MQAQEAVSRV KRMQKAAKIK
KKATSEGDSQ ALTEVDLFIS TQRIKVLNAD TQETMMDHAL RTISYIADIG NIVVLMARRR
MPRSASQDCI ETTPGGQEGK KQYKMICHVF ESEDAQLIAQ SIGQAFSVAY QEFLRANGIN
PEDLSQKEYS DIINTQEMYN DDLIHFSNSE NCKELQLEKQ KGEILGVVIV ESGWGSILPT
VILANMMNGG PAARSGKLSI GDQIMSINGT SLVGLPLATC QGIIKGLKNQ TQVKLNIVSC
PPVTTVLIKR PDLKYQLGFS VQNGIICSLM RGGIAERGGV RVGHRIIEIN GQSVVATAHE
KIVQALSNSV GEIHMKTMPA AMFRLLTGQE TPLYI
//
