ID U3KE97_FICAL Unreviewed; 388 AA.
AC U3KE97;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Neuromedin B receptor {ECO:0000313|Ensembl:ENSFALP00000013351.1};
GN Name=NMBR {ECO:0000313|Ensembl:ENSFALP00000013351.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000013351.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000013351.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000013351.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR RefSeq; XP_005043768.1; XM_005043711.1.
DR AlphaFoldDB; U3KE97; -.
DR STRING; 59894.ENSFALP00000013351; -.
DR Ensembl; ENSFALT00000013407.2; ENSFALP00000013351.1; ENSFALG00000012792.2.
DR GeneID; 101813542; -.
DR KEGG; fab:101813542; -.
DR CTD; 4829; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01100000263512; -.
DR HOGENOM; CLU_009579_6_2_1; -.
DR OMA; GHNLKQE; -.
DR OrthoDB; 2905228at2759; -.
DR Proteomes; UP000016665; Chromosome 3.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0004946; F:bombesin receptor activity; IEA:InterPro.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
DR GO; GO:0090290; P:positive regulation of osteoclast proliferation; IEA:Ensembl.
DR GO; GO:1903942; P:positive regulation of respiratory gaseous exchange; IEA:Ensembl.
DR GO; GO:0160023; P:sneeze reflex; IEA:Ensembl.
DR CDD; cd15125; 7tmA_NMBR; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001556; Bombsn_rcpt-like.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001642; NeuroB_rcpt.
DR PANTHER; PTHR45695; LEUCOKININ RECEPTOR-RELATED; 1.
DR PANTHER; PTHR45695:SF8; NEUROMEDIN-B RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00358; BOMBESINR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00639; NEUROMEDINBR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..322
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 388 AA; 43409 MW; 804DD4D7D0387D00 CRC64;
MEPELPPELA AVPLGENGSV RLVPDTALLS PGRGTAMFII RCVIPSLYLL IITVGLLGNI
TLMKIFISNS AMRSVPNIFI SSLAAGDLLL LVTCVPVDAS RYFSEEWLFG EVGCKLIPVI
QLTSVGVSVF TLTALSADRY KAIVNPMDIQ TSSAVLWTCL KATAIWVISM LLAVPEAVFS
ELAHINDTDN ATFTACIPYP MSDDMHPKIH SVLLFLVYFL IPLVIISIYY YHIAKSLIKS
AHNIPGEHSE HSKRQMETRK RLAKIVLVFV GFFAICWFPN HVLYMYRSFH YNKIDPSMGH
MVVTLVARVL SFCNSCVNPF ALYFLSESFR RHFNNQLRCR KKAQKERSAS YLCNSSAIQM
TSLKSNTRNT VTTMTQLNGH NLKQEMSL
//
