ID U3KGH1_FICAL Unreviewed; 836 AA.
AC U3KGH1;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Phosphatidylinositol-glycan-specific phospholipase D {ECO:0000256|ARBA:ARBA00015988};
DE EC=3.1.4.50 {ECO:0000256|ARBA:ARBA00012284};
DE AltName: Full=Glycosyl-phosphatidylinositol-specific phospholipase D {ECO:0000256|ARBA:ARBA00029753};
GN Name=GPLD1 {ECO:0000313|Ensembl:ENSFALP00000014125.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000014125.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000014125.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000014125.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-
CC myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a
CC 1,2-diacyl-sn-glycero-3-phosphate + H(+); Xref=Rhea:RHEA:10832,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57997,
CC ChEBI:CHEBI:58608, ChEBI:CHEBI:58700; EC=3.1.4.50;
CC Evidence={ECO:0000256|ARBA:ARBA00034002};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the GPLD1 family.
CC {ECO:0000256|ARBA:ARBA00008652}.
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DR RefSeq; XP_016152058.1; XM_016296572.1.
DR AlphaFoldDB; U3KGH1; -.
DR STRING; 59894.ENSFALP00000014125; -.
DR Ensembl; ENSFALT00000014183.2; ENSFALP00000014125.1; ENSFALG00000013533.2.
DR GeneID; 101816045; -.
DR CTD; 2822; -.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00390000013522; -.
DR HOGENOM; CLU_011756_0_0_1; -.
DR OMA; CGMTTHN; -.
DR OrthoDB; 1332649at2759; -.
DR Proteomes; UP000016665; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0004621; F:glycosylphosphatidylinositol phospholipase D activity; IEA:UniProtKB-EC.
DR GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0071277; P:cellular response to calcium ion; IEA:Ensembl.
DR GO; GO:0071397; P:cellular response to cholesterol; IEA:Ensembl.
DR GO; GO:0071467; P:cellular response to pH; IEA:Ensembl.
DR GO; GO:0071401; P:cellular response to triglyceride; IEA:Ensembl.
DR GO; GO:0071466; P:cellular response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0002430; P:complement receptor mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0006507; P:GPI anchor release; IEA:Ensembl.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0010595; P:positive regulation of endothelial cell migration; IEA:Ensembl.
DR GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR GO; GO:1900076; P:regulation of cellular response to insulin stimulus; IEA:Ensembl.
DR GO; GO:0009749; P:response to glucose; IEA:Ensembl.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR001028; Gprt_PLipase_D.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR008947; PLipase_C/P1_nuclease_dom_sf.
DR InterPro; IPR029002; PLPC/GPLD1.
DR PANTHER; PTHR23221; GLYCOSYLPHOSPHATIDYLINOSITOL PHOSPHOLIPASE D; 1.
DR PANTHER; PTHR23221:SF7; PHOSPHATIDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D; 1.
DR Pfam; PF01839; FG-GAP; 3.
DR Pfam; PF00882; Zn_dep_PLPC; 1.
DR PRINTS; PR00718; PHPHLIPASED.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF48537; Phospholipase C/P1 nuclease; 1.
DR PROSITE; PS51470; FG_GAP; 4.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..836
FT /note="Phosphatidylinositol-glycan-specific phospholipase
FT D"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004645643"
FT DOMAIN 28..205
FT /note="Phospholipase C/D"
FT /evidence="ECO:0000259|Pfam:PF00882"
FT REPEAT 368..429
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 437..498
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 500..560
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 703..769
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 836 AA; 92419 MW; 662F485820D1A200 CRC64;
MVGLKIWFVL LVILYRFCQR CIPCGISTHV EIAHRALEFF IKHEGSVNYR QLLLNHQDAF
QAGSIYPDAF YPPICKRGMF HDVSEDTHWS PFLKTSIDYI RRNYPQPWEE ATEKLVAFLF
GIASHMVADV SWHSLGIDQG FLKAMGEIDF HGSYSEAHSV GDFGGDVVSQ FELDFSYLAS
SWYVPVKDLA AIYKEFYGKE IITESTIAEC TYLLFFELHG ERLLVGKLFP TFASKSPFLV
EKFHEYFLGG VDDMAFWTNN IFELTSHMLE NGTSDCYLPE NPLFINCTKE HKENHIRNKQ
SKHEHHKNTT SLLTETLEKN INYTERGVQF NIQPWATKSL RLINHAFKNN VWRALAATHQ
KSSKHISKPA ASYFLTSPYA RLGWALISAD LNQDGYEDLV AGAPGYSTMG HFQIGRVYVV
YGNQSGLPPE DMDLDGKADQ ILEGHQPSGR FGSALAVLDF NEDGVPDLAI GAPSVGSQFL
TYKGAVYVYF GTEGRGLAPQ PNVTITCQYS YCNFGWSLLA ADVDGNGNAD LVVGSPYAPG
GGKQRGFVVA FYSHFNRSDQ GLLSVQDANW MVEGEENYAW FGFSLASCQL ENVTLLLIGS
PTWKTCSSCN PLLPDVRQSV GKVYGYSPPS TERWFEITGD KEMGRMGLSL ASGVLSVAGK
TRKVLVAGAP TADSSSRILF MSSVLHQAGL ALVYDLSNST KPSLLSTFSG DKRFSRFGGD
IYLSDLDSDG LDEMIVASPL RTNGVTSILS GGAAGRVYIY NGRQASSGNV TGHCTSWTSP
CPEDWAQYVL ISPEELSRFG SSITTVKSGT KKELVVAAER SSAKARLGGR LFVYSL
//
