ID U3KIH9_FICAL Unreviewed; 549 AA.
AC U3KIH9;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Leucine-rich repeat transmembrane neuronal protein 1 {ECO:0000256|ARBA:ARBA00044114};
GN Name=LRRTM1 {ECO:0000313|Ensembl:ENSFALP00000014833.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000014833.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000014833.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000014833.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Exhibits strong synaptogenic activity, restricted to
CC excitatory presynaptic differentiation, acting at both pre- and
CC postsynaptic level. {ECO:0000256|ARBA:ARBA00043936}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00035006}; Single-pass
CC type I membrane protein {ECO:0000256|ARBA:ARBA00035006}.
CC -!- SIMILARITY: Belongs to the LRRTM family.
CC {ECO:0000256|ARBA:ARBA00038250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; U3KIH9; -.
DR STRING; 59894.ENSFALP00000014833; -.
DR Ensembl; ENSFALT00000014897.2; ENSFALP00000014833.2; ENSFALG00000014217.2.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000161705; -.
DR HOGENOM; CLU_032965_0_0_1; -.
DR OrthoDB; 5344967at2759; -.
DR Proteomes; UP000016665; Chromosome 4.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0098982; C:GABA-ergic synapse; IEA:Ensembl.
DR GO; GO:0030426; C:growth cone; IEA:Ensembl.
DR GO; GO:0099634; C:postsynaptic specialization membrane; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0035640; P:exploration behavior; IEA:Ensembl.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR GO; GO:0002091; P:negative regulation of receptor internalization; IEA:Ensembl.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR GO; GO:0035418; P:protein localization to synapse; IEA:Ensembl.
DR GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
DR GO; GO:0050808; P:synapse organization; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR24373:SF290; LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 1; 1.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 3.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..97
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
FT REGION 400..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 62588 MW; 179EDB461A79AB49 CRC64;
MEVVTLWKRN LKRFNGHSQA YLEIFLLMDF LLIGLCLNWL LRKPPGLILC TLGIFSKMLP
AVNSGCPQLC RCEGRLLYCE SLNLTEMPRN LSGMMGLSLR YNSLSELHDG QFTGLMQLTW
LYLDHNHICS VEGNAFQKLR RVKELTLSSN KITQLPNTTF RPMPNLRSVD LSYNNLQSLE
PDLFHGLRKL TTLHMRSNAI KFVPVRIFQD CRSLKFLDIG YNQLKSLARN SFAGLFKLTE
LHLEHNDLVK VNLAHFPRLI SLHSLCLRRN KVTIVVNTLD WIWQLEKMDL SGNEIEYIEP
HVFESVPHLK SLQLDSNRLT YIDSRVLDSW KSLTSISLSA NAWDCSRNVC ALASWLSNFQ
GRYDSNLLCA TPEYAQGEDV LDAVYAFHLC EDDADPTSVN TFSPVTNNSE QTPGYGSATA
TYDAPDGDED RTTYAVTITM PGENSENAVQ IHKVVTGTMA LIFSFLIVVL VLYVSWKCFP
AGLRQLRQCF VTQRRKQKQK QTMHQMAAMS AQEYYVDYKP NHIEGALVII NEYGSCSCHQ
QPARECEVQ
//