ID U3KMU0_RABIT Unreviewed; 658 AA.
AC U3KMU0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Coatomer subunit gamma-2 {ECO:0000256|ARBA:ARBA00039447};
DE AltName: Full=Gamma-2-coat protein {ECO:0000256|ARBA:ARBA00041406};
GN Name=COPG2 {ECO:0000313|Ensembl:ENSOCUP00000026549.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000026549.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000026549.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000026549.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000026549.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000026549.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPI-coated vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004347}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004347}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004347}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004255}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004255}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004255}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the COPG family.
CC {ECO:0000256|ARBA:ARBA00010720}.
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DR EMBL; AAGW02062261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02062262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02062263; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02062264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; U3KMU0; -.
DR Ensembl; ENSOCUT00000033502.2; ENSOCUP00000026549.2; ENSOCUG00000022849.3.
DR GeneTree; ENSGT00390000016313; -.
DR HOGENOM; CLU_010353_2_1_1; -.
DR Proteomes; UP000001811; Chromosome 7.
DR Bgee; ENSOCUG00000022849; Expressed in embryo and 15 other cell types or tissues.
DR ExpressionAtlas; U3KMU0; baseline.
DR GO; GO:0030126; C:COPI vesicle coat; IEA:InterPro.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.1480; Coatomer, gamma subunit, appendage domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR017106; Coatomer_gsu.
DR InterPro; IPR013040; Coatomer_gsu_app_Ig-like_dom.
DR InterPro; IPR037067; Coatomer_gsu_app_sf.
DR PANTHER; PTHR10261; COATOMER SUBUNIT GAMMA; 1.
DR PANTHER; PTHR10261:SF4; COATOMER SUBUNIT GAMMA-2; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF08752; COP-gamma_platf; 1.
DR PIRSF; PIRSF037093; Coatomer_gamma_subunit; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 42..472
FT /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01602"
FT DOMAIN 545..646
FT /note="Coatomer gamma subunit appendage Ig-like subdomain"
FT /evidence="ECO:0000259|Pfam:PF08752"
SQ SEQUENCE 658 AA; 73646 MW; 196D1180E05710A4 CRC64;
MYTCGEHFGT TEATEAFFAM TRLFQPYTLQ NVKCLLTFSE TVLTKDMTGK EDVYRGPAIR
ALCRITDGTM LQAIERYMKQ AIVDKVSSVS SSALVSSLHM MKISYDVVKR WINEAQEAAS
SDNIMVQYHA LGVLYHLRKN DRLAVSKMLN KFTKSGLKSQ FAYCMLIRIA SRLLKETEDG
HESPLFDFIE SCLRNKHEMV IYEAASAIIH LPNCTARELA PAVSVLQLFC SSPKPALRYA
AVRTLNKVAM KHPSAVTACN LDLENLITDS NRSIATLAIT TLLKTGSESS VDRLMKQISS
FVSEISDEFK VVVVQAISAL CQKYPRKHSV MMTFLSNMLR DDGGFDYKRA IVDCIISIVE
ENPESKEAGL AHLCEFIEDC EHTVLATKIL HLLGKEGPRT PIPSKYIRFI FNRVVLENEA
VRAAAVSALA KFGAQNENLL PSILVLLQRC MMDTDDEVRD RATFYLNVLQ QRQMALNATY
ICNGLTVSVP GMEKALHQYT LEPSEKPFDM KSVPLAMAPV FEQKAEITLV ATKPEKLAPS
RQDIFQEQLA AIPEFMNLGP LFKSSDPVQL TEAETEYFVR CIKHIFTHHI VFQFDCTNTL
NDQLLEKVTV QMEPSDSCEV LCCIPAASLT YNQPGICYTL VRLPDDDPTA GCSDSSTR
//
