ID U3KMV1_RABIT Unreviewed; 998 AA.
AC U3KMV1;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 {ECO:0000313|Ensembl:ENSOCUP00000026560.2};
GN Name=HERC6 {ECO:0000313|Ensembl:ENSOCUP00000026560.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000026560.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000026560.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000026560.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000026560.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000026560.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02022573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02022574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02022575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; U3KMV1; -.
DR SMR; U3KMV1; -.
DR STRING; 9986.ENSOCUP00000026560; -.
DR PaxDb; 9986-ENSOCUP00000026560; -.
DR Ensembl; ENSOCUT00000033514.2; ENSOCUP00000026560.2; ENSOCUG00000029688.2.
DR eggNOG; KOG0941; Eukaryota.
DR GeneTree; ENSGT00940000162279; -.
DR HOGENOM; CLU_002173_5_5_1; -.
DR InParanoid; U3KMV1; -.
DR Proteomes; UP000001811; Chromosome 15.
DR Bgee; ENSOCUG00000029688; Expressed in blood and 18 other cell types or tissues.
DR ExpressionAtlas; U3KMV1; baseline.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR PANTHER; PTHR45622:SF58; HECT AND RLD DOMAIN CONTAINING E3 UBIQUITIN LIGASE 4, ISOFORM C; 1.
DR PANTHER; PTHR45622; UBIQUITIN-PROTEIN LIGASE E3A-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 4.
DR Pfam; PF13540; RCC1_2; 1.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 3.
DR PROSITE; PS50012; RCC1_3; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 81..134
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 135..187
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 188..242
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 243..293
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 671..994
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 962
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 998 AA; 111749 MW; 3CFC4120D8D5486A CRC64;
MYWCWGADAG KPRHQRVAGG AELRQAASGE RHSLLLLTDG TIQSCGDNGR GQLGRKSRCP
AERPEQIQTL ETLQVEFVSC GKGALPGCLP TRGQLGTGDF KETTFIPSKI KALTDIKIIQ
VACGHYHSLA LSADSQVFSW GKNSQGQLGL GKEFPSQASP QRVRSLQGIP VAQVAAGGAH
SFVLSLSGTS FGWGNNSAGQ LALSGDNVPV QSPKPRSIGA LEKLGVIYIS CGSEHTAVLT
QDGKVFTFGD NSFGQLGHSS TAEKRGPQLV EGIDGLVSQI DCGSYHTLAF VYTTGQVVCF
GCGARDRSNP TPPEDLPEDV GVSCLISADD LVDVQVKHIF AGTYANFVTT SQDAGSTRVP
RKTLPEISQI NQSLMEKWIA VKRRSSEQEV AKREIRMIFS SPACLTASFL KKRGTGEGIS
MDVDLQKARD TFKKLTEENW ISSLIQTSLE DNLLKALPCH SPHQEALLIF LLLPECPMMC
DSENSNKLVA PFAEAVCNMS SKSLQILKRC WASLQESSLN TLIQMLKTAV VSLAYGPRTY
QNDNNLKVLL GMMKKVHKVN KTICRLPENT FNIDELDNLN FYTETKRRLF RKQNMKTAEN
SSLVVFSDFP FIFNLQSKIK LLQADLKMIE MTEIFLKHQL LQRNPEPPIF QLRVRRSHLV
EDALRQLNTA ESSDFCKELV VGFVKEIRPE SGGVRSEFFH CIFEEMTKPE YGMFMYPENG
SFMWFPVTPQ CDKNNYLLFG ILCGLSLLHC NVANLPFPLA LYKKLLDQKP SLEDLKELSP
LLGKNLQEIL NGEADDFEDL SMYFSIHWDQ NNVALIPNGI SIPVDQSNKK DYVSQCVDYI
FNVSVKAVYE KFQRGFYKVC DKDIIEYFHP EELMTAVVGN SDYDWEQFEK NSKYLEGYHE
SDRTIVLFWK AFHKLTLDEK KKFLFFLTGC DKFHARGLQQ IGILFRCPKT MSEKDSPRSL
TCHCILDLPK YSTMKRMEEA LQVAIRNNRG FTSPEITL
//
