ID U3KNQ0_RABIT Unreviewed; 428 AA.
AC U3KNQ0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Leucine rich repeat containing 28 {ECO:0000313|Ensembl:ENSOCUP00000026859.2};
GN Name=LRRC28 {ECO:0000313|Ensembl:ENSOCUP00000026859.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000026859.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000026859.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000026859.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000026859.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR AlphaFoldDB; U3KNQ0; -.
DR STRING; 9986.ENSOCUP00000026859; -.
DR Ensembl; ENSOCUT00000033811.2; ENSOCUP00000026859.2; ENSOCUG00000006434.4.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000157771; -.
DR InParanoid; U3KNQ0; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000006434; Expressed in ovary and 18 other cell types or tissues.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF45; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 10B; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 6.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..428
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023928208"
SQ SEQUENCE 428 AA; 48477 MW; 782161F8A15D10B0 CRC64;
MMRFVLSVRM WLFASRLTWQ CFQVPHSDSP LCSLCRHGPI GRDVVLRGPD GICSVMASEL
SKTISVARQE KHKNLFLNYR NLHHFPLELL KDEGLQHLER LYMKRNSLTT LPENLAQKLP
NLVELYLHSN NIVVVPEAIG SLVKLQCLDL SDNALEIVCP EIGRLRALRH LRLANNQLQF
LPPEVGDLKE LQTLDISTNR LLTLPERLHL CLSLQYLTAD RNRLWYVPRH LCQLPSLNEL
SMAGNCLAFL PPDLGRSREL QYVYVDNNVH LKGLPSYLYN KVIGCSGCGA PLHVPEVKLL
SFSSGQLTVS LPAEVKAIGT ESDRVLPLQE LAMRRLHHAH RGLRTDLNFL SPVSLPRSLL
ELLHCPLGHC HRCSEPMFTI VYPKLFPLRE TPMAGLHQGA RQLLVYFPPL QISLPRSWGC
SAESRGQP
//
