ID U3KNR8_RABIT Unreviewed; 864 AA.
AC U3KNR8;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=PMS1 homolog 1, mismatch repair system component {ECO:0000313|Ensembl:ENSOCUP00000026877.2};
GN Name=PMS1 {ECO:0000313|Ensembl:ENSOCUP00000026877.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000026877.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000026877.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000026877.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000026877.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000026877.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; AAGW02003506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02003507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02003508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; U3KNR8; -.
DR Ensembl; ENSOCUT00000033829.2; ENSOCUP00000026877.2; ENSOCUG00000012511.4.
DR GeneTree; ENSGT00940000157085; -.
DR Proteomes; UP000001811; Chromosome 7.
DR Bgee; ENSOCUG00000012511; Expressed in liver and 15 other cell types or tissues.
DR ExpressionAtlas; U3KNR8; baseline.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd21985; HMG-box_PMS1; 1.
DR CDD; cd03485; MutL_Trans_hPMS_1_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF54; PMS1 PROTEIN HOMOLOG 1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 503..571
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 503..571
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 455..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 97813 MW; 9960484B4C1C7F32 CRC64;
MAVKYYTSKI NSHEDLERLT TYGFRGEALG SICCVAEVSI TTRTAADNFS TQYVLDSSGH
IVSQKPSHLG QGTTVTALRL FKNLPVRKQF YSTAKKCKDE IKKVQDLLIS YGILKPDLRI
VFVHNKAVVW QKTKVSDHKM ALMSVLGTAV MGNMESFQCC SEESQVSLSG FLPKRDADHS
LTSLSTPERS FIFINSRPIH QKDILKLIRQ YYTLKCLKES TRLYPIFFLK IDVPTADVDV
NLTPDKSQVL LQNKESVLIA LENLMTTCYG PLPSTNSCES NKTDVSLADM VVTKTAETDV
LFNKMESSGN NHSNVDTATV SFQNDVYNDE SGEGTNLGLN QQTSVGVHCD SHFSSENASI
GKNTRNTSQE IPVNNLSWED AQSGYGETCL VGSIKHVQSE NGSKIYTNES GRLEEEAVPE
KSLEICADDW SKGNAFKNSM GENIEPVKIL VPQESSACKA SDNNHPSPEQ TKLSEGPSNK
KSNVIDNKTG QLTAYDLISS RVIRKPMSAS ALFVQDHRPQ FLTENPKTSM EEATVQIEEL
WKTLSEEERL KYEEKATKDL ERYNNQMKRA LEQESQIPLK DGRKKIKHTS AWNLAQKHKL
KASLSNQPKL DELFQSHVEK KRNDNIKIVS IPFSMEKLKV NFEKQNKFDL EDKDEQCFIH
NLSFPDAWLM ISKTEVMLLN PYRVEEALLF KRLLENHKLP AEPLEKPIIL TESLFNGSHY
LEILYKMTAD DQQYSGSTYL SDPRLTANGF KIKLIPGVSI AENYLEIEGM ANCLPFYGIT
DLKEILNAIL YKNAKEIFEC RPRKVINYLE GEAVRLSRQL PMYLPKEDIQ DIIYRMKHQF
GNEIKGCVHG RPFFHHLTHI PETT
//