ID U3KP08_RABIT Unreviewed; 1040 AA.
AC U3KP08;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Transmembrane protein 132D {ECO:0000313|Ensembl:ENSOCUP00000026968.2};
GN Name=TMEM132D {ECO:0000313|Ensembl:ENSOCUP00000026968.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000026968.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000026968.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000026968.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000026968.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the TMEM132 family.
CC {ECO:0000256|ARBA:ARBA00006166}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; U3KP08; -.
DR STRING; 9986.ENSOCUP00000026968; -.
DR PaxDb; 9986-ENSOCUP00000026968; -.
DR Ensembl; ENSOCUT00000033920.2; ENSOCUP00000026968.2; ENSOCUG00000029668.2.
DR eggNOG; KOG4789; Eukaryota.
DR GeneTree; ENSGT00940000158942; -.
DR HOGENOM; CLU_009871_0_0_1; -.
DR InParanoid; U3KP08; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000029668; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR026307; TMEM132.
DR InterPro; IPR031436; TMEM132_C.
DR InterPro; IPR031437; TMEM132_M.
DR InterPro; IPR031435; TMEM132_N.
DR PANTHER; PTHR13388:SF2; TRANSMEMBRANE PROTEIN 132D; 1.
DR PANTHER; PTHR13388; UNCHARACTERIZED; 1.
DR Pfam; PF16070; TMEM132; 1.
DR Pfam; PF15706; TMEM132D_C; 1.
DR Pfam; PF15705; TMEM132D_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..1040
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023906652"
FT TRANSMEM 871..896
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..177
FT /note="Transmembrane protein TMEM132 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF15705"
FT DOMAIN 433..731
FT /note="Transmembrane protein family 132 middle"
FT /evidence="ECO:0000259|Pfam:PF16070"
FT DOMAIN 841..924
FT /note="Transmembrane protein TMEM132 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF15706"
FT REGION 240..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..766
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..839
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1040 AA; 113766 MW; 053588C981CC7612 CRC64;
MCASEMGTPW HHWSPVLISL AALFSKVTES RGILESIQRF SLLPTYLPVT YHVDHADVSF
FLKEADQDVM RNSSLQSRVE SFLVYKSRRL PVLSASYGPF SVERVVPQDL LLPSNPFRFT
SAFSLNWKLN AFVLRDRIDL SRPQVQVLFH VAGRDWREPR AGERLPCLRL FAFRETREVR
AGCRLAGPLG LCVAELELPP SWFSPPTVVA GRRRPGDPAE GSPVELYYTM QPVDAQGNCA
RQDSRRHGEP WAGHGDMDES GPPPHRIGSV FLYQTRGPPP LRELRLDSNV AIHYTPKTVR
QGDVLTFPVS VSRNSTQGDF TLRAKVKKGV RITGVRASSP AVWDVRQSSE STAKYAPAVI
VCRKKSAGPE DSMDGPSYEV MQIDIEVEEP SDPPSTQLVT WQVEYPRDIT SDLGVSKIYV
SLKDLSGVIP LAMVSDRCDF VFVNGKEMKG KVGVEVSFTY QHLSSPLRMT VWAPRLPLHI
EVSDTELNQI KGWRVPVVSS KRPVRDSEEE EDEERRGRGC TLQYQHAMVR VLTQFVAEAA
GPGGHLAHLL GSDWQVDITE LVRDFMQVEE PRVATLQGGQ ILVGQELGMT TLQILSPLSD
AILAEKTVTV LDERVTITDL GVQLVTGLSL ALQLSPGSNR AIFATAVAQE LLQRPKQEAA
ISCWVQFSDG SVTPLDIYDG KDFSLLVTSL DEKVVSIRQD PKAQWPVITA ETEGQGALVK
VEMAISESCQ KSKRKSILAV GTASVRVKFG QNDATPNTSN SGQPGPGARL ETGISDRRPR
RPQQEWGRPE GQHHGSSSRG LTEGRGATTE RATFWRGRGQ GSPTDGNSGH WQAFPTDLAS
SPDQGEPPGG GAEVDDSDPL QASKGLSDLE IGMYALLGVF CLAIVVFLAN CATFALRYRH
KQVPVEEQEG LSHSHAWLGL SHRTEPLGSH VHFASPQLEQ VTCLDQGLDL EESKYLLSTD
PQKGGLNGQL LQPPAAGGGD GTGPGEPLAS PASRRKRVRF STFTALTPPS APGTGSEDDL
KWACQALGPG DSPARPREAV
//
