ID U3KPN2_RABIT Unreviewed; 574 AA.
AC U3KPN2;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Transmembrane protein 132C {ECO:0008006|Google:ProtNLM};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000027192.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000027192.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000027192.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000027192.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; U3KPN2; -.
DR STRING; 9986.ENSOCUP00000027192; -.
DR PaxDb; 9986-ENSOCUP00000027192; -.
DR Ensembl; ENSOCUT00000034143.2; ENSOCUP00000027192.2; ENSOCUG00000029463.2.
DR eggNOG; KOG4789; Eukaryota.
DR GeneTree; ENSGT00940000154702; -.
DR HOGENOM; CLU_009871_2_0_1; -.
DR InParanoid; U3KPN2; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000029463; Expressed in embryo and 7 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026307; TMEM132.
DR InterPro; IPR031436; TMEM132_C.
DR InterPro; IPR031437; TMEM132_M.
DR PANTHER; PTHR13388:SF4; TRANSMEMBRANE PROTEIN 132C; 1.
DR PANTHER; PTHR13388; UNCHARACTERIZED; 1.
DR Pfam; PF16070; TMEM132; 1.
DR Pfam; PF15706; TMEM132D_C; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 397..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..262
FT /note="Transmembrane protein family 132 middle"
FT /evidence="ECO:0000259|Pfam:PF16070"
FT DOMAIN 366..450
FT /note="Transmembrane protein TMEM132 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF15706"
FT REGION 279..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 574 AA; 61436 MW; 3A3057BB1836C4EB CRC64;
IRGQVDVAVN FTYQHLSAPL LVTVWVPRLP LQIQVSDTEL SQIKGWRVPI VATRKRRRRR
SGGAGGCALQ FQRATVRVLT EFVSQGAGPW GQPSHLLGPD WQFDITHLAG RVLVGREVGM
TTIQVLSPLS DSILAEKTVT VLDDKVSVTD LAIQLVAGLS ATLHPDAEDG QAITAVATAE
ELLRTPKQEA VVSTWLQFSD GSVTPVDIYD AKDFSLTATS LDETIVSVPQ ARSPRWPVVV
AEGEGEGPLV RVDLAIAEAC QKSKRKSVLA VGFGNVRVKF GQSDTDSSPG EDLGGEEEIK
NHASGRRQKA QGQDGRLPGS SSLEREEGAL WRVPATAKSP VGNRAGKSSR LDGEAQPQNI
PLDFTRFPAQ GEPPRAGAGP EGGDLVQRPR GLSDLEIGMY ALLGVFCLAI VVFLVNCATF
ALRYRHKQVP VEGQAPAPHS HDWVWLGNEA ELLENAGEGP APQHERTTVI DRGLGGHEES
GHLPLTGGSQ KHVQSQVHRP PAPGPGQEPP HSPTSRRKKV QFSTFTAIPP DDGCPTVDSI
GGGHGEDIKW VCPDMAVGGP RDPGDCLEKL KAKA
//
