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Database: UniProt
Entry: U4K1Z0_9VIBR
LinkDB: U4K1Z0_9VIBR
Original site: U4K1Z0_9VIBR 
ID   U4K1Z0_9VIBR            Unreviewed;       358 AA.
AC   U4K1Z0;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   08-MAY-2019, entry version 37.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   Name=aroF {ECO:0000313|EMBL:CCO56571.1};
GN   ORFNames=VIBNI_A0374 {ECO:0000313|EMBL:CCO56571.1};
OS   Vibrio nigripulchritudo.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Vibrio.
OX   NCBI_TaxID=28173 {ECO:0000313|EMBL:CCO56571.1, ECO:0000313|Proteomes:UP000016895};
RN   [1] {ECO:0000313|EMBL:CCO56571.1, ECO:0000313|Proteomes:UP000016895}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SnF1 {ECO:0000313|Proteomes:UP000016895};
RX   PubMed=23739050; DOI=10.1038/ismej.2013.90;
RA   Goudenege D., Labreuche Y., Krin E., Ansquer D., Mangenot S.,
RA   Calteau A., Medigue C., Mazel D., Polz M.F., Le Roux F.;
RT   "Comparative genomics of pathogenic lineages of Vibrio
RT   nigripulchritudo identifies virulence-associated traits.";
RL   ISME J. 7:1985-1996(2013).
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; FO203526; CCO56571.1; -; Genomic_DNA.
DR   RefSeq; WP_004397935.1; NZ_JXXT01000027.1.
DR   STRING; 1238450.VIBNISOn1_1110010; -.
DR   EnsemblBacteria; CCO56571; CCO56571; VIBNI_A0374.
DR   GeneID; 29462156; -.
DR   KEGG; vni:VIBNI_A0374; -.
DR   PATRIC; fig|1260221.3.peg.353; -.
DR   KO; K01626; -.
DR   OrthoDB; 853329at2; -.
DR   BioCyc; VNIG28173:VIBNI_RS01815-MONOMER; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000016895; Chromosome.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016895};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156, ECO:0000313|EMBL:CCO56571.1}.
FT   DOMAIN       41    340       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
FT   COILED       67     87       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   358 AA;  39608 MW;  683068E1495F3251 CRC64;
     MQKSELSNIH ISDEQVLITP NALKEKIPLS ENARRFIQQS RQEIANILDK KDHRLLVVCG
     PCSIHDIDAA KEYAKRLKAL SEKLNDQLYI VMRVYFEKPR TTVGWKGLIN DPHLNGTFDI
     EHGLHVARQL LVDLAEMEIP LATEALDPIS PQYLADTFSW AAIGARTTES QTHREMASGL
     SMPVGFKNGT DGSLATAINA MQAASSGHRF MGINREGQVA LLTTQGNPHG HVILRGGKQT
     NYDSVSVAEC EEEMAKSGLD AALMVDCSHA NSRKDFSRQP LVAEDVIHQI REGNKSIIGL
     MIESHINEGN QASDIPVDQM AYGVSITDAC INWDTTEALL THAHQELVPF LEDRIKDQ
//
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