ID   U4KEY1_9VIBR            Unreviewed;       784 AA.
AC   U4KEY1;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Putative exporter of the RND superfamily {ECO:0000313|EMBL:CCO57528.1};
GN   ORFNames=VIBNI_A1399 {ECO:0000313|EMBL:CCO57528.1};
OS   Vibrio nigripulchritudo.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=28173 {ECO:0000313|EMBL:CCO57528.1, ECO:0000313|Proteomes:UP000016895};
RN   [1] {ECO:0000313|EMBL:CCO57528.1, ECO:0000313|Proteomes:UP000016895}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SnF1 {ECO:0000313|Proteomes:UP000016895};
RX   PubMed=23739050; DOI=10.1038/ismej.2013.90;
RA   Goudenege D., Labreuche Y., Krin E., Ansquer D., Mangenot S., Calteau A.,
RA   Medigue C., Mazel D., Polz M.F., Le Roux F.;
RT   "Comparative genomics of pathogenic lineages of Vibrio nigripulchritudo
RT   identifies virulence-associated traits.";
RL   ISME J. 7:1985-1996(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FO203526; CCO57528.1; -; Genomic_DNA.
DR   RefSeq; WP_022550456.1; NC_022528.1.
DR   AlphaFoldDB; U4KEY1; -.
DR   STRING; 28173.VIBNI_A1399; -.
DR   KEGG; vni:VIBNI_A1399; -.
DR   PATRIC; fig|1260221.3.peg.1340; -.
DR   eggNOG; COG1033; Bacteria.
DR   OrthoDB; 9803781at2; -.
DR   Proteomes; UP000016895; Chromosome 1.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016895};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        229..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        282..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        353..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        407..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        606..628
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        635..655
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        661..682
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        703..726
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        738..761
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          253..378
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   DOMAIN          633..760
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   784 AA;  86126 MW;  D6961FB62AD2859B CRC64;
     MKVQQNLLTR LLRSPISHTP WVLLLTTILL VVATIGGKNL YFRGDYNIFF DGANPQLQAF
     EEIQATFNKT DNLAIVIAPA DGNVFTPETL NLVRDFTEDS WQVPFSSRVD SLSNYQHTEA
     FEDDLLVEDL LLEDYELTQE RIEKVKQVAL SEPVLLKSVV SESGDVTIVN ITLQLPKIDE
     TAELIQVVAF ADQLLAKYQA QYPSVTFHKA GIVAMNDAFM VSAQNDTSTL VPAMLAVVLV
     FLTIMLRSFL SVVATLVVII GSVTATMGLS GWAGMFLSTA TVNIPTLVLT LAVADCVHVI
     ATMRQAMLEG KSKSEAISHS IWLNFMPILI TSVTTAIGFL MMNMSDSPVL RDFGNLAALG
     VMIACILSVT LLPALLKVLP IKVKPQAQNK ATYMDKFGAF VVRQRKVLLP LSVAVIAVSA
     ALVPQNKIND ESVKYFDQTS AFRQAADFME EHISGMTNIN IAIKTGESQG IADPTFLTTL
     GEFTDWLRAQ PETDHVASLA DVYKRLNKNM HGDDQSYYTL PQERELAAQY LLMYEMSLPY
     GLDLNNQINV DKSSVKLVLT TRNLGSKELV DIENRIYDWF ATNAPQYDIS ASSPTLMFAH
     IGETNMASML STLPITLILI SALMIFALRS FRLGVISLVP NMAPAVIGFG MWALYSGEIN
     LGLSVVVTLT LGIVVDDAVH FLSKYQRARK EGKDAEQAVR YAFNTVGRAL GITTVVLVAG
     FSILAMSSFR LNADMGQLSA LVIFLALVVD FLFLPTLLML FDKDKAPAED TKEAISLNKT
     ETVS
//