ID U4KM42_9MOLU Unreviewed; 1085 AA.
AC U4KM42;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=addA {ECO:0000313|EMBL:CCV65041.1};
GN ORFNames=BN85300200 {ECO:0000313|EMBL:CCV65041.1};
OS Paracholeplasma brassicae.
OC Bacteria; Mycoplasmatota; Mollicutes; Acholeplasmatales;
OC Acholeplasmataceae; Paracholeplasma.
OX NCBI_TaxID=61635 {ECO:0000313|EMBL:CCV65041.1, ECO:0000313|Proteomes:UP000032737};
RN [1] {ECO:0000313|EMBL:CCV65041.1, ECO:0000313|Proteomes:UP000032737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0502 {ECO:0000313|Proteomes:UP000032737};
RX PubMed=24158107; DOI=10.1159/000354322;
RA Kube M., Siewert C., Migdoll A.M., Duduk B., Holz S., Rabus R.,
RA Seemuller E., Mitrovic J., Muller I., Buttner C., Reinhardt R.;
RT "Analysis of the Complete Genomes of Acholeplasma brassicae , A. palmae and
RT A. laidlawii and Their Comparison to the Obligate Parasites from '
RT Candidatus Phytoplasma'.";
RL J. Mol. Microbiol. Biotechnol. 24:19-36(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; FO681348; CCV65041.1; -; Genomic_DNA.
DR RefSeq; WP_030003915.1; NC_022549.1.
DR AlphaFoldDB; U4KM42; -.
DR STRING; 61635.BN85300200; -.
DR KEGG; abra:BN85300200; -.
DR HOGENOM; CLU_001114_3_1_14; -.
DR Proteomes; UP000032737; Chromosome Acholeplasma brassicae.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000032737}.
FT DOMAIN 9..449
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 30..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1085 AA; 127278 MW; 1FA687E424891DAF CRC64;
MIPKKPKESY YTDHQWQAIH QKNSNVLISA GAGSGKTSVL TERVLRILNE GIDINRLLIL
TFTKAASLEM KERIRKNLEK AIKNAPNPHL ERQLELLDVS FITTFDSFCL YLVKKYNHKL
GIKKDIQIGD ENLFKQQKKR IIQDLFQSLY EENNEDFFAY LRTYTTKSDE KLEDQLLFLA
EQLQKYDLDE TYLDTYEQTY YGKNYQEKLT HALIEKVTEF KQGLQKLNND LSLLALESES
GQDTKTRLEN EIASLLSFED LTSFNRYTEE KESFKITLKT SRDDRSLLKP YLDSFKDLLN
LYQPYFSHSI ETHNQTHEKN KPHVLFLLSL AFRFLASYSA FQDHLGIYDF LSISSLSTKL
LKDHEDVRNE LKHFYHELLI DEFQDTSLIQ NIFISQIENN NVFMVGDIKQ SIYRFRDAKP
ELFQQKYDLF KAQPTAGIKI DLNQNFRSRK EILEDINTLF YRTMSPRIGG VTYDGLQALV
FGNQTYEKQK ANQPYGIEIL EVLSKEELED HEKTYKTDES QVFSIIKDIK DKMASKYQVL
DSKTNQLRDV KFDDFVILID RKSPFRLFKA VAEANQVPMY LHATEPFVSN DDVLALRSLL
SLFYCFKDAS YGKDHFTHDF LSVFRSYLFQ INDQILHDSL NALKNHSYFD YKKVLSNETI
ITTLDKLNAL NVLSETLSLD LFLIEVTKTF NLLEKALVLN QIEAIESRLF YLIDKAKSLS
KLNFGLLELL EYFSFINEED LDLDFQSSSK LKEGMVNVMT IHKSKGLEFS ICYYPMLDKR
WSSPNLSNFY FDLTYGIIMP SFDEGLTDNI EKQLHLAQEK QEMISERLRL FYVALTRAKE
LAVIVANPPS NETFINEIKS DELVDESIRN NYNSFNQLVY TVIGHYAKKR IKAPYDEIIY
NENYKDSIQK QRVHFKKEQV FNYKALSYKP KQIKKERISG NFVEIKDEQT LKDMALGTLI
HEQLERLDFC LPLKNQIDQL PVDNNVKKFL YKLDRLPFLH DLKEAFIYQE YEFIVSTDDQ
VKQGIIDLLI ETNEALIVVD YKLKDINKPI YFSQLEGYKD YLSTKSNKPI RAYLYSLIDG
VYLEV
//
