ID U4KWD1_PYROM Unreviewed; 646 AA.
AC U4KWD1;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Similar to Ubiquitin carboxyl-terminal hydrolase 1 acc. no. P25037 {ECO:0000313|EMBL:CCX05777.1};
GN ORFNames=PCON_05364 {ECO:0000313|EMBL:CCX05777.1};
OS Pyronema omphalodes (strain CBS 100304) (Pyronema confluens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Pyronemataceae; Pyronema.
OX NCBI_TaxID=1076935 {ECO:0000313|EMBL:CCX05777.1};
RN [1] {ECO:0000313|EMBL:CCX05777.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS100304 {ECO:0000313|EMBL:CCX05777.1};
RC TISSUE=Vegetative mycelium {ECO:0000313|EMBL:CCX05777.1};
RX PubMed=24068976; DOI=10.1371/journal.pgen.1003820;
RA Traeger S., Altegoer F., Freitag M., Gabaldon T., Kempken F., Kumar A.,
RA Marcet-Houben M., Poggeler S., Stajich J.E., Nowrousian M.;
RT "The genome and development-dependent transcriptomes of Pyronema confluens:
RT a window into fungal evolution.";
RL PLoS Genet. 9:E1003820-E1003820(2013).
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DR EMBL; HF935273; CCX05777.1; -; Genomic_DNA.
DR AlphaFoldDB; U4KWD1; -.
DR STRING; 1076935.U4KWD1; -.
DR eggNOG; KOG1867; Eukaryota.
DR OMA; VNACTED; -.
DR OrthoDB; 1749511at2759; -.
DR Proteomes; UP000018144; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR CDD; cd02662; Peptidase_C19F; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006:SF936; C-TERMINAL HYDROLASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:CCX05777.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 102..503
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 556..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 646 AA; 70021 MW; 7629524DB1B60C3E CRC64;
MPSSYRSYHQ PPRYQHSQPP LNIPIPASTV ATVVAVCFAI LYYCLSDFLQ LPSGFDLIAR
MAGVLFGPAA REKLQHVFST SPRQAMSKVV RKPFGGKGGS VGGLWNTGNT CYQNSVLQSL
ASLESLKSWL SSIEDGVAAE ALQDLVEELN EVTEKPRVKT ASTAITQGSG GVKGWMFNEQ
QDAQEFLQGL MGVLEKEMAE VVKYNKEDNV IGLEGALDEK APEVTVPEDS TTRSPFEGLL
AQRVGCLNCG YVEGISLQPF TTLSLPIPSS WTVTLEDCLS AFTAIEPIQG VDCDKCTLNA
VQQRLQNLLA TSEDPSADPS TALTPVIRET IATRLAAVNA ALEEDNFTPK IPGVKLDGAH
KVSSTKTKQV MISRTPEVLV LHTNRSTFDM NTGMMSKNHA TVRFPATLNL SKFITSHENL
STDPGQPISV LKPVEGGDEE TQGGFYELKA IVTHYGGHHN GHYVAYRSWA NRWWRISDHD
VNACTEDDAL AAGNAFMLFY ERLSPEALQQ RRAASKAAIV AMSTEVAINI PLPDSEPASE
DEDWDGVNVS VNSSQLLLTP PDSESGVGNC GSGDDTEGNN MLRQEHTPPP EPETGDPDIV
YAVPKDVVLE PLQTPEDEVP LVAVSLATPP ASTNSTPVRK RKKRKS
//
