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Database: UniProt
Entry: U4L022_PYROM
LinkDB: U4L022_PYROM
Original site: U4L022_PYROM 
ID   U4L022_PYROM            Unreviewed;       359 AA.
AC   U4L022;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   08-MAY-2019, entry version 26.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=PCON_07443 {ECO:0000313|EMBL:CCX07854.1};
OS   Pyronema omphalodes (strain CBS 100304) (Pyronema confluens).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC   Pezizales; Pyronemataceae; Pyronema.
OX   NCBI_TaxID=1076935 {ECO:0000313|EMBL:CCX07854.1, ECO:0000313|Proteomes:UP000018144};
RN   [1] {ECO:0000313|EMBL:CCX07854.1, ECO:0000313|Proteomes:UP000018144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 100304 {ECO:0000313|Proteomes:UP000018144};
RC   TISSUE=Vegetative mycelium {ECO:0000313|EMBL:CCX07854.1};
RX   PubMed=24068976; DOI=10.1371/journal.pgen.1003820;
RA   Traeger S., Altegoer F., Freitag M., Gabaldon T., Kempken F.,
RA   Kumar A., Marcet-Houben M., Poggeler S., Stajich J.E., Nowrousian M.;
RT   "The genome and development-dependent transcriptomes of Pyronema
RT   confluens: a window into fungal evolution.";
RL   PLoS Genet. 9:E1003820-E1003820(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; HF935378; CCX07854.1; -; Genomic_DNA.
DR   STRING; 337075.U4L022; -.
DR   OMA; CIGWEAT; -.
DR   OrthoDB; 1034517at2759; -.
DR   Proteomes; UP000018144; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018144};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018144};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361}.
FT   DOMAIN       44    342       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   359 AA;  38831 MW;  17569656832798E3 CRC64;
     MSNVQTENVR VVGQDPLISP AGLQTKFPAT DASKATVLKG RQDSISVITG ESDKLLVIVG
     PCSIHDPETA YEYAKLLIAL RDELKDDLVI IMRAYLEKPR TTVGWKGLIN DPDIDESFQI
     NKGLQVSRDL FVQLNNMGIP IASEMLDTIS PQFLADCLSI AAIGARTTES QLHRELASGV
     SFPVGFKNGT DGSLGVAIDA VLSASHPHHF MGVTKDGLAA ITKTTGNEHG FVILRGGSKG
     PNYSPEDVKA TKEQLKKKNQ RQIMMIDCSH GNSNKNHKNQ PLVAESIASQ LRAGEEGIIG
     VMIESNLGEG RQDVPKEGKA GLKKGVSITD ACINWEDTEK VLKNLAQAVR ERREKRASA
//
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