ID U4L195_PYROM Unreviewed; 269 AA.
AC U4L195;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=5-formyltetrahydrofolate cyclo-ligase {ECO:0000256|ARBA:ARBA00038966};
DE EC=6.3.3.2 {ECO:0000256|ARBA:ARBA00038966};
GN ORFNames=PCON_05436 {ECO:0000313|EMBL:CCX05849.1};
OS Pyronema omphalodes (strain CBS 100304) (Pyronema confluens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Pyronemataceae; Pyronema.
OX NCBI_TaxID=1076935 {ECO:0000313|EMBL:CCX05849.1};
RN [1] {ECO:0000313|EMBL:CCX05849.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS100304 {ECO:0000313|EMBL:CCX05849.1};
RC TISSUE=Vegetative mycelium {ECO:0000313|EMBL:CCX05849.1};
RX PubMed=24068976; DOI=10.1371/journal.pgen.1003820;
RA Traeger S., Altegoer F., Freitag M., Gabaldon T., Kempken F., Kumar A.,
RA Marcet-Houben M., Poggeler S., Stajich J.E., Nowrousian M.;
RT "The genome and development-dependent transcriptomes of Pyronema confluens:
RT a window into fungal evolution.";
RL PLoS Genet. 9:E1003820-E1003820(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-
CC methenyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:10488,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57455,
CC ChEBI:CHEBI:57457, ChEBI:CHEBI:456216; EC=6.3.3.2;
CC Evidence={ECO:0000256|ARBA:ARBA00036539};
CC -!- SIMILARITY: Belongs to the 5-formyltetrahydrofolate cyclo-ligase
CC family. {ECO:0000256|ARBA:ARBA00010638}.
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DR EMBL; HF935274; CCX05849.1; -; Genomic_DNA.
DR AlphaFoldDB; U4L195; -.
DR STRING; 1076935.U4L195; -.
DR eggNOG; KOG3093; Eukaryota.
DR OMA; DKWGIPT; -.
DR OrthoDB; 5490047at2759; -.
DR Proteomes; UP000018144; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.10420; NagB/RpiA/CoA transferase-like; 1.
DR InterPro; IPR002698; FTHF_cligase.
DR InterPro; IPR024185; FTHF_cligase-like_sf.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR23407:SF1; 5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE; 1.
DR PANTHER; PTHR23407; ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE; 1.
DR Pfam; PF01812; 5-FTHF_cyc-lig; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000313|EMBL:CCX05849.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
SQ SEQUENCE 269 AA; 29425 MW; AE61E38DED116450 CRC64;
MTSDLLLDST GVPTPRSITP MTVAPTLHTA KRALRTKVKG ILKTLPADSI RAQSDTILRT
VLNLPEYKNA RSLSIYLSMP KGEVTTGALV TASLEAGKQV FVPYIHRQPP SHPIASSASL
AASASAPPSL MDMLSLSSLS DFQGFQPDSW GIPTIPEDGR SERQDGLKAG LDLIIMPGVA
FSEEFKRCGH GKGFYDYFLT RYNQARQAEE VKEEEASGVE TSQVRQRKMP VLVALALKEQ
MVEEVPTDLS DWYMDVVVTG DGRCLRREA
//
