ID   U4L1B2_PYROM            Unreviewed;       351 AA.
AC   U4L1B2;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Similar to Adenosine deaminase-like protein A acc. no. Q4V831 {ECO:0000313|EMBL:CCX08247.1};
GN   ORFNames=PCON_07840 {ECO:0000313|EMBL:CCX08247.1};
OS   Pyronema omphalodes (strain CBS 100304) (Pyronema confluens).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC   Pezizales; Pyronemataceae; Pyronema.
OX   NCBI_TaxID=1076935 {ECO:0000313|EMBL:CCX08247.1};
RN   [1] {ECO:0000313|EMBL:CCX08247.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS100304 {ECO:0000313|EMBL:CCX08247.1};
RC   TISSUE=Vegetative mycelium {ECO:0000313|EMBL:CCX08247.1};
RX   PubMed=24068976; DOI=10.1371/journal.pgen.1003820;
RA   Traeger S., Altegoer F., Freitag M., Gabaldon T., Kempken F., Kumar A.,
RA   Marcet-Houben M., Poggeler S., Stajich J.E., Nowrousian M.;
RT   "The genome and development-dependent transcriptomes of Pyronema confluens:
RT   a window into fungal evolution.";
RL   PLoS Genet. 9:E1003820-E1003820(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + H2O + N(6)-methyl-AMP = IMP + methylamine;
CC         Xref=Rhea:RHEA:16001, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:59338, ChEBI:CHEBI:144842;
CC         Evidence={ECO:0000256|ARBA:ARBA00036622};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16002;
CC         Evidence={ECO:0000256|ARBA:ARBA00036622};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
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DR   EMBL; HF935403; CCX08247.1; -; Genomic_DNA.
DR   AlphaFoldDB; U4L1B2; -.
DR   STRING; 1076935.U4L1B2; -.
DR   eggNOG; KOG1097; Eukaryota.
DR   OMA; RPQFKPY; -.
DR   OrthoDB; 20281at2759; -.
DR   Proteomes; UP000018144; Unassembled WGS sequence.
DR   GO; GO:0019239; F:deaminase activity; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR   PANTHER; PTHR11409:SF42; ADENOSINE DEAMINASE-LIKE PROTEIN; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   4: Predicted;
FT   DOMAIN          9..337
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   351 AA;  39802 MW;  5A74D581D79D14C4 CRC64;
     MKEFCKRLPK IELHAHLSGS IRRDTLHHIW QQKKSESPEL TLEDPLLVIP EEGVKDINAF
     FPLFSKYIYA LINTVSTVEF STRAVLNDFC ADGVVYLELR TTPRDFPETG LTKQKYVETV
     LNTISEFNAS NGEMKARLIL SIDRRDDVEK AWETVELAKR YKKEGVSGVD LCGDPLKGDP
     SIFAPHFDAA KSAGLGLTIH FAELPQSSSD SELFTLLSYN PDRLGHVIHC SEEVKKKLVE
     KKVALELCIS CNVQIKMNPA VTTHKEHHFG EWWREGNCTV ALSTDDVGVF YSELSNEYWI
     VHEHFGLGKR QLWELAKGVV DATFAEKEEK ERLKGVMDKF GAAEGLWQID M
//