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Database: UniProt
Entry: U4L1T0_PYROM
LinkDB: U4L1T0_PYROM
Original site: U4L1T0_PYROM 
ID   U4L1T0_PYROM            Unreviewed;      1080 AA.
AC   U4L1T0;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   05-JUN-2019, entry version 33.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=PCON_08154 {ECO:0000313|EMBL:CCX08561.1};
OS   Pyronema omphalodes (strain CBS 100304) (Pyronema confluens).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC   Pezizales; Pyronemataceae; Pyronema.
OX   NCBI_TaxID=1076935 {ECO:0000313|EMBL:CCX08561.1, ECO:0000313|Proteomes:UP000018144};
RN   [1] {ECO:0000313|EMBL:CCX08561.1, ECO:0000313|Proteomes:UP000018144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 100304 {ECO:0000313|Proteomes:UP000018144};
RC   TISSUE=Vegetative mycelium {ECO:0000313|EMBL:CCX08561.1};
RX   PubMed=24068976; DOI=10.1371/journal.pgen.1003820;
RA   Traeger S., Altegoer F., Freitag M., Gabaldon T., Kempken F.,
RA   Kumar A., Marcet-Houben M., Poggeler S., Stajich J.E., Nowrousian M.;
RT   "The genome and development-dependent transcriptomes of Pyronema
RT   confluens: a window into fungal evolution.";
RL   PLoS Genet. 9:E1003820-E1003820(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; HF935419; CCX08561.1; -; Genomic_DNA.
DR   STRING; 337075.U4L1T0; -.
DR   OMA; CLVNYTE; -.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000018144; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018144};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018144};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      106    449       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      513    944       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      982   1056       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     72       Disordered. {ECO:0000256|MobiDB-lite:
FT                                U4L1T0}.
FT   COMPBIAS     14     31       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                U4L1T0}.
FT   COMPBIAS     32     46       Polar. {ECO:0000256|MobiDB-lite:U4L1T0}.
FT   COMPBIAS     47     72       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                U4L1T0}.
SQ   SEQUENCE   1080 AA;  122495 MW;  D5F4F734B409E4AC CRC64;
     MPASTGKRSL GADSASGAKK RRVEDGIKND RLTKLSQSVP KSSFEEELDQ MSQDIDLKGN
     SDKDQKWARP DLGDWDPERE DLLFQQIDVE EGNLNGKTAI RLFGVTEAGH SVLLHVTDFL
     HYIYVAAPVG FDQEHTTPFR DFLDTKLANG REKMIEKVEI FMRENLYHYN GNVKSPYLKI
     STTDPKHIPR LRTMIERGEA NWKGMWPIGD SGCMTFDSIQ YVMRFMVDTG VSGMSWVEAP
     AGTYNILPKN TSVSNCQIEA SVSYKDLIAH GTDGEFAKMA PLRILSFDIE CAGRKGIFPE
     ANHDPVIQIA NVVTRYGEDK PFVRNVFCLD TCALIVNTQL FEYQDEKQML VGWKNFLQEV
     DPDVIIGYNT ANFDMPYLLD RAKHLGAGEF PFWTRLANMK TEAKDSNFSS KQMGNRDTKA
     TNTNGRLQID MLQVIQRDHQ LRSYTLNSVS AHFLGEQKED VHHSMITELF NGTPESRRRL
     AVYCLKDAYL PQRLLDKLMC LVNYTEMARV TGVPFNYLLS RGQQIKFLSQ IFRKALEEGL
     VIPNLKSEAS DDQYEGATVI EPTRGYYDVP IATLDFASLY PSIMQAHNLC YTTLLRKETA
     QRLNLKEGHD YTVTPNGDWF VKANRRKGMV PLILEGLLGA RKRAKNDLKN ETDPFKKAVL
     NGRQLALKIS ANSVYGITGA TVGKLPCLAI ASSVTSFGRE MIMKTREEVE KHYTIANGYD
     HDAQVIYGDT DSVMVKFGPK DLATAMKLGE EAANLVSSKF ITPIKLEFEK VYFPYLLINK
     KRYAGLYWTR TEKYDKMDSK GIETVRRDNC RLVQVCIETV LKKLLIDRDV DGAQIYVKNL
     ISDLLQNRID MSQLVITKAL SKVDYASKQA HTELVERMKK RDVGSAPTLG DRVAYVIIKG
     AANAKNYEKS EDPLYVLENS VPIDTKYYLD NQLAKPLGRI FEPIVGEKKA QQLLTGDHTR
     IITVSAPTVG GLMKFAKKTQ TCMGCKTPLN KKGQTEGAVC ENCRPRFGEL YQKSLTKVNE
     MQVRFGRLWT QCQRCQGAIH CEVICSNKDC PIFYMRMKAR KDLQDREKEL KRFDMGELTW
//
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