ID U4L9S0_PYROM Unreviewed; 978 AA.
AC U4L9S0;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Similar to Oxysterol-binding protein homolog C23H4.01c acc. no. O13944 {ECO:0000313|EMBL:CCX15440.1};
GN ORFNames=PCON_01715 {ECO:0000313|EMBL:CCX15440.1};
OS Pyronema omphalodes (strain CBS 100304) (Pyronema confluens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Pyronemataceae; Pyronema.
OX NCBI_TaxID=1076935 {ECO:0000313|EMBL:CCX15440.1};
RN [1] {ECO:0000313|EMBL:CCX15440.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS100304 {ECO:0000313|EMBL:CCX15440.1};
RC TISSUE=Vegetative mycelium {ECO:0000313|EMBL:CCX15440.1};
RX PubMed=24068976; DOI=10.1371/journal.pgen.1003820;
RA Traeger S., Altegoer F., Freitag M., Gabaldon T., Kempken F., Kumar A.,
RA Marcet-Houben M., Poggeler S., Stajich J.E., Nowrousian M.;
RT "The genome and development-dependent transcriptomes of Pyronema confluens:
RT a window into fungal evolution.";
RL PLoS Genet. 9:E1003820-E1003820(2013).
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|ARBA:ARBA00008842}.
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DR EMBL; HF936168; CCX15440.1; -; Genomic_DNA.
DR AlphaFoldDB; U4L9S0; -.
DR STRING; 1076935.U4L9S0; -.
DR eggNOG; KOG1737; Eukaryota.
DR OMA; SYFVRWV; -.
DR OrthoDB; 960at2759; -.
DR Proteomes; UP000018144; Unassembled WGS sequence.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13289; PH_Osh3p_yeast; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.60.120.680; GOLD domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR036598; GOLD_dom_sf.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972:SF216; OXYSTEROL-BINDING PROTEIN HOMOLOG 3; 1.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF101576; Supernatant protein factor (SPF), C-terminal domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 205..299
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 46..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..556
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 978 AA; 108888 MW; 98216C9FAC0BE655 CRC64;
MEQLEIPSRS YIIRWVDCAP GNTIQWSVKP HKKSLNFGIF RHPGNSASSG ASIRPPNTAR
SEESTTSTIR EQQLQQRATP TTTRYNTGDC IDKIHAAGLL DIYWHGKCEA EKVTSGTYQV
KTQGGMFALV FDNTFSKQIA KTATFVLLTY PTNAPPPASH ALHHADSSNQ LGVPLTQTIS
RQTITSPSAE VLSMHSVDRE EPGSQGFQTG ILKKRKRKRH QGYARRYFSL DYTSCTLSYY
MSKESSALRG AIPLSLAAIS ASKVNREICI DSGAEVWHLR ADNDRDWDTW KLALERAAQH
AAKQSTGDMS SLNLQVPGQE QMIDPSPAND QHIIMEERGW AGVEALVGRV SGVRDAVRRL
AMQAQEQPQQ VPSEVASSAA SVMSIPIGDD KSAAGAAKRP FWKRKASAQT PSPGNMPTSP
RPGSSRTINT VNTPATPGAQ QDISFNLQAL LSDLDSVVSD FSSLISQNKQ RRWATNRTSI
YRSNRSNRTS TFGSGKNAAS SRMSMESTAS EEFFDAEDAL EGDRVVMLDH DDDEGVREEA
AEEENEATDN EESDEEDSPT APPRPSSQPT EPVVTNGIKD LSPLPLELVQ RRNTVPEAKV
LPPSLIGFLR KNVGKDLSTI AMPVSANEPI SLLQRMSEQL EYSELLDAAA SAPAETGERI
LLVAAFAISS FSGARIKERA IRKPFNPMLG ETFELVREDK GFRFLSEKVS HRPVIMACHA
DHALWSFSQS PQPTQKFWGK SAELITSGRV RINFHQTGDK FSYTVATSFL RNIIAGEKYV
EPTGTMHIHN ETTGEKAVVT FKMNKGMFSG RSEEVSVQAF DAEGGAYNLI LMGKWTENLM
LVDDTTSEQR EIWRVADLVD GAPQRYGWTE FAAQLNQITE IEAGNIAPTD SRNRPDQRMV
EEGRLDEAEG IKLKLEEKQR DRRREMEEEG KVWEPVWFRK VREYADEEVW RIVGDEEEGY
WKKRQEKDWN NTTGVFEV
//
