ID   U4LFG1_PYROM            Unreviewed;       689 AA.
AC   U4LFG1;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Similar to Translocation protein sec63 acc. no. Q9HGN7 {ECO:0000313|EMBL:CCX13719.1};
GN   ORFNames=PCON_13312 {ECO:0000313|EMBL:CCX13719.1};
OS   Pyronema omphalodes (strain CBS 100304) (Pyronema confluens).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC   Pezizales; Pyronemataceae; Pyronema.
OX   NCBI_TaxID=1076935 {ECO:0000313|EMBL:CCX13719.1};
RN   [1] {ECO:0000313|EMBL:CCX13719.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS100304 {ECO:0000313|EMBL:CCX13719.1};
RC   TISSUE=Vegetative mycelium {ECO:0000313|EMBL:CCX13719.1};
RX   PubMed=24068976; DOI=10.1371/journal.pgen.1003820;
RA   Traeger S., Altegoer F., Freitag M., Gabaldon T., Kempken F., Kumar A.,
RA   Marcet-Houben M., Poggeler S., Stajich J.E., Nowrousian M.;
RT   "The genome and development-dependent transcriptomes of Pyronema confluens:
RT   a window into fungal evolution.";
RL   PLoS Genet. 9:E1003820-E1003820(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; HF935887; CCX13719.1; -; Genomic_DNA.
DR   AlphaFoldDB; U4LFG1; -.
DR   STRING; 1076935.U4LFG1; -.
DR   eggNOG; KOG0721; Eukaryota.
DR   OMA; RAILHAH; -.
DR   OrthoDB; 1605at2759; -.
DR   Proteomes; UP000018144; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 1.10.287.110; DnaJ domain; 1.
DR   Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR004179; Sec63-dom.
DR   PANTHER; PTHR24075; SEC63 DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR24075:SF0; TRANSLOCATION PROTEIN SEC63 HOMOLOG; 1.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF02889; Sec63; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SMART; SM00973; Sec63; 1.
DR   SUPFAM; SSF46565; Chaperone J-domain; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   4: Predicted;
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        13..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        75..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        201..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          107..177
FT                   /note="J"
FT                   /evidence="ECO:0000259|PROSITE:PS50076"
FT   REGION          614..689
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        660..689
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   689 AA;  76284 MW;  CFE7795F51CA3213 CRC64;
     MSTDYSYDDK GQFFPYFVAT ILGLILVPLS YSTFAPSQQL RASNKPLITS PDYDAPRYEK
     VEAARRRQAK KERRLKRFTA LVFGWAALGY VCYLISISTN PEGNTWDPYT ILGIGTSATE
     KAIKSHYKKM SLKFHPDKIR PGPNETIEML NERFVEITKA YKALTDEEMR NNYIEYGHPD
     GKQPTSIGIA LPKWVVSEGN TYYVLMVYGL LFGILLPYTV GKWWYGTKKL TKDGVVVESA
     GKLFKEYDEE MDEAQLVRIL TAGEEVKEIT SGSREKEWAN SEDATIEKKL LAAGLRPSQL
     GALEKYEGWR RRAITLLWAY LYRIDLGNDA LDIAKLDVAA AAVTLNRSVN SICMAFGNLG
     PLLTSLRLSQ FIIQAIAPGQ SPLLQLPHFT EAIADAVERE GGKNHWTVAA LMSLPEKERK
     ARLIGPGLLT EPQYKTAMTF AKSMPSLKIE AAFFKVVGEK AITPSSLITF VVKARVIPPG
     VTAPAINPKD LLDEDPDESD IEALLGRKKG ENKSKDAIAA AGQLPLAHAP FYPRDHHPGW
     YIFLGDVRQG KIVVPPTPVT AFDKDPAGFT VVTTKMQFQA PPQEGEFPFT MLCVSDTYIG
     VETQMSVTLK VQEASAGEWE DVDDISEPDE DSIAGQMNAM RGSAAPPKKK KKSPAAAKEE
     SDSEEEESDT DGAEEISDTD TETEDEDDS
//