ID U4LH45_PYROM Unreviewed; 1157 AA.
AC U4LH45;
DT 11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Similar to Helicase required for RNAi-mediated heterochromatin assembly 1 acc. no. O74465 {ECO:0000313|EMBL:CCX31434.1};
GN ORFNames=PCON_10781 {ECO:0000313|EMBL:CCX31434.1};
OS Pyronema omphalodes (strain CBS 100304) (Pyronema confluens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Pyronemataceae; Pyronema.
OX NCBI_TaxID=1076935 {ECO:0000313|EMBL:CCX31434.1};
RN [1] {ECO:0000313|EMBL:CCX31434.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS100304 {ECO:0000313|EMBL:CCX31434.1};
RC TISSUE=Vegetative mycelium {ECO:0000313|EMBL:CCX31434.1};
RX PubMed=24068976; DOI=10.1371/journal.pgen.1003820;
RA Traeger S., Altegoer F., Freitag M., Gabaldon T., Kempken F., Kumar A.,
RA Marcet-Houben M., Poggeler S., Stajich J.E., Nowrousian M.;
RT "The genome and development-dependent transcriptomes of Pyronema confluens:
RT a window into fungal evolution.";
RL PLoS Genet. 9:E1003820-E1003820(2013).
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DR EMBL; HF935596; CCX31434.1; -; Genomic_DNA.
DR AlphaFoldDB; U4LH45; -.
DR STRING; 1076935.U4LH45; -.
DR eggNOG; KOG1807; Eukaryota.
DR OMA; EWIMVEA; -.
DR OrthoDB; 7041at2759; -.
DR Proteomes; UP000018144; Unassembled WGS sequence.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF341; NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:CCX31434.1};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000313|EMBL:CCX31434.1};
KW Hydrolase {ECO:0000313|EMBL:CCX31434.1};
KW Nucleotide-binding {ECO:0000313|EMBL:CCX31434.1}.
FT DOMAIN 414..786
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 801..989
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 1..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1107..1138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 598..628
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 70..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1157 AA; 131568 MW; E17A210175E8A859 CRC64;
MTDEWDTKQA EAEVADGDGW FNSAADAEYT WDLPEEEVTT DKNSTTATES DGFQLQGKRL
RRKDVRQHKA SKRSTREHGA IEVSRDAPEE HHFKEKFAQR GDKRKSRKAE WKSELDQMAE
LRQRLQKLGG RNGLGSDTSK QLIVPSNPLV AKYEQETTDH YGEEWRRIPL VPSSEELERE
DVEVPVNTID GPWESVEEYL STHYELIRED VTAGLRDAVM SIRQNPLLDD NHSMAIYENV
IVKGLTFNLI MGVAVKVSFS LNRAGKKVKW KGSKRLVAGT LVCISQDNFQ TFKVATVAAR
PMSGLELDPP EVDLLFNVDE LEIDVNKPFL MVESRSGYFE AFKWVLRAMQ RMSEKTMALH
NHIVGLDREV GHPQYVVDNP MYNLESVFPD PSNQDLVKEM NILEEWPPEL KNTMDESQTE
ALRTILTKRI AIIQGPPGTG KTYTSVMALH ALLQNMSEDD PPIIVACQTN HALDQLLKHV
YEFEQDIIRL GGRTKETGPI KERTMFNVRK LASNVIIQGG NPGHYSRQMD NVRQKMVELL
QPLLPDFFSP ETLFEYGQIN AKQQTSLVDG VNDWVTACDD NKPSSIMALW LRDSIMPVQR
AENIYSNMEE AEANYEALLD QEAEFQSGPG NVDDFKEELQ GFWQSIIHKY TVRPEEGDNA
SIDKAMNTTN MWKIPAGLRA AVYERWAGEV TRQIREKIIV LNKEFSKLSQ QLKIARMQKD
AFLISQSKLV GMTTTGLSKY RSLIAACKPR VILIEEAAEV LEAPVLVGCL PDIQQMILVG
DHQQLKGKCN VKDLEGEPYF LDTSLFERLV ENDMPYVTLR TQRRMRPEIR EVLHPIYDDL
LIDHDSVLGR EDIQGMGGVN VYWHCHNQYE SSTADSPSKR NVFEAGMIAG FVNYLIHNGT
APEKITILTF YTGQQAEIFI GLRRYEPLKR HLRTIKIVTV DSYQGEENDI VILSLVRSNS
EQKIGFLENE NRVCVALSRA QRGFYVFGDI ALLSGQSVIW WEIGKIFNKS PSRVGYKLPI
TCQRHNTRTM IEDHFEWIDI DGGCRLPCGE TREDCGHKCF LKCHPLSHDK YPCAEPCLKK
IPICGHTCSG GCGQACRCER CGHWADPPEE EDEEAEKEEQ TKAKEVENKN LGFGGISKPV
EKVRRRKTGK YANAVRG
//
